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Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

Author

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  • Yuhao Cheng

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Hao Cheng

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Chenxiao Jiang

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Xuefeng Qiu

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Kaikai Wang

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Wei Huan

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Ahu Yuan

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Jinhui Wu

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University)

  • Yiqiao Hu

    (State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University
    Jiangsu Key Laboratory for Nano Technology, Nanjing University)

Abstract

Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen (1O2) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by loading a photosensitizer into perfluorocarbon nanodroplets. Because of the higher oxygen capacity and longer 1O2 lifetime of perfluorocarbon, the photodynamic effect of the loaded photosensitizer is significantly enhanced, as demonstrated by the accelerated generation of 1O2 and elevated cytotoxicity. Following direct injection into tumours, in vivo studies reveal tumour growth inhibition in the Oxy-PDT-treated mice. In addition, a single-dose intravenous injection of Oxy-PDT into tumour-bearing mice significantly inhibits tumour growth, whereas traditional PDT has no effect. Oxy-PDT may enable the enhancement of existing clinical PDT and future PDT design.

Suggested Citation

  • Yuhao Cheng & Hao Cheng & Chenxiao Jiang & Xuefeng Qiu & Kaikai Wang & Wei Huan & Ahu Yuan & Jinhui Wu & Yiqiao Hu, 2015. "Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy," Nature Communications, Nature, vol. 6(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9785
    DOI: 10.1038/ncomms9785
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    Cited by:

    1. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Elizabeth Zoneff & Yi Wang & Colin Jackson & Oliver Smith & Serena Duchi & Carmine Onofrillo & Brooke Farrugia & Simon E. Moulton & Richard Williams & Clare Parish & David R. Nisbet & Lilith M. Caball, 2024. "Controlled oxygen delivery to power tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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