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A redox signalling globin is essential for reproduction in Caenorhabditis elegans

Author

Listed:
  • Sasha De Henau

    (Ghent University)

  • Lesley Tilleman

    (University of Antwerp)

  • Matthew Vangheel

    (Ghent University)

  • Evi Luyckx

    (University of Antwerp)

  • Stanislav Trashin

    (University of Antwerp)

  • Martje Pauwels

    (University of Antwerp)

  • Francesca Germani

    (University of Antwerp)

  • Caroline Vlaeminck

    (Ghent University)

  • Jacques R. Vanfleteren

    (Ghent University)

  • Wim Bert

    (Ghent University)

  • Alessandra Pesce

    (University of Genova)

  • Marco Nardini

    (University of Milano)

  • Martino Bolognesi

    (University of Milano
    CNR-IBF and CIMAINA, University of Milano)

  • Karolien De Wael

    (University of Antwerp)

  • Luc Moens

    (University of Antwerp)

  • Sylvia Dewilde

    (University of Antwerp)

  • Bart P. Braeckman

    (Ghent University)

Abstract

Moderate levels of reactive oxygen species (ROS) are now recognized as redox signalling molecules. However, thus far, only mitochondria and NADPH oxidases have been identified as cellular sources of ROS in signalling. Here we identify a globin (GLB-12) that produces superoxide, a type of ROS, which serves as an essential signal for reproduction in C. elegans. We find that GLB-12 has an important role in the regulation of multiple aspects in germline development, including germ cell apoptosis. We further describe how GLB-12 displays specific molecular, biochemical and structural properties that allow this globin to act as a superoxide generator. In addition, both an intra- and extracellular superoxide dismutase act as key partners of GLB-12 to create a transmembrane redox signal. Our results show that a globin can function as a driving factor in redox signalling, and how this signal is regulated at the subcellular level by multiple control layers.

Suggested Citation

  • Sasha De Henau & Lesley Tilleman & Matthew Vangheel & Evi Luyckx & Stanislav Trashin & Martje Pauwels & Francesca Germani & Caroline Vlaeminck & Jacques R. Vanfleteren & Wim Bert & Alessandra Pesce & , 2015. "A redox signalling globin is essential for reproduction in Caenorhabditis elegans," Nature Communications, Nature, vol. 6(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9782
    DOI: 10.1038/ncomms9782
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