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Basal forebrain control of wakefulness and cortical rhythms

Author

Listed:
  • Christelle Anaclet

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Nigel P. Pedersen

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    Comprehensive Epilepsy Clinic, Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Loris L. Ferrari

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Anne Venner

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Caroline E. Bass

    (School of Medicine and Biomedical Sciences, University at Buffalo)

  • Elda Arrigoni

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Patrick M. Fuller

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Wakefulness, along with fast cortical rhythms and associated cognition, depend on the basal forebrain (BF). BF cholinergic cell loss in dementia and the sedative effect of anti-cholinergic drugs have long implicated these neurons as important for cognition and wakefulness. The BF also contains intermingled inhibitory GABAergic and excitatory glutamatergic cell groups whose exact neurobiological roles are unclear. Here we show that genetically targeted chemogenetic activation of BF cholinergic or glutamatergic neurons in behaving mice produced significant effects on state consolidation and/or the electroencephalogram but had no effect on total wake. Similar activation of BF GABAergic neurons produced sustained wakefulness and high-frequency cortical rhythms, whereas chemogenetic inhibition increased sleep. Our findings reveal a major contribution of BF GABAergic neurons to wakefulness and the fast cortical rhythms associated with cognition. These findings may be clinically applicable to manipulations aimed at increasing forebrain activation in dementia and the minimally conscious state.

Suggested Citation

  • Christelle Anaclet & Nigel P. Pedersen & Loris L. Ferrari & Anne Venner & Caroline E. Bass & Elda Arrigoni & Patrick M. Fuller, 2015. "Basal forebrain control of wakefulness and cortical rhythms," Nature Communications, Nature, vol. 6(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9744
    DOI: 10.1038/ncomms9744
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    Cited by:

    1. Jilin W J L Wang & Fabrizio Lombardi & Xiyun Zhang & Christelle Anaclet & Plamen Ch Ivanov, 2019. "Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture," PLOS Computational Biology, Public Library of Science, vol. 15(11), pages 1-35, November.
    2. Roberto Luca & Stefano Nardone & Kevin P. Grace & Anne Venner & Michela Cristofolini & Sathyajit S. Bandaru & Lauren T. Sohn & Dong Kong & Takatoshi Mochizuki & Bianca Viberti & Lin Zhu & Antonino Zit, 2022. "Orexin neurons inhibit sleep to promote arousal," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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