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Identification and characterization of latency-associated peptide-expressing γδ T cells

Author

Listed:
  • Rafael M. Rezende

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Andre P. da Cunha

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Chantal Kuhn

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Stephen Rubino

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Hanane M’Hamdi

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
    Rheumatology Unit, Karolinska Institute)

  • Galina Gabriely

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Tyler Vandeventer

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Shirong Liu

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Ron Cialic

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Natalia Pinheiro-Rosa

    (Institute of Biological Sciences, Federal University of Minas Gerais)

  • Rafael P. Oliveira

    (Institute of Biological Sciences, Federal University of Minas Gerais)

  • Jellert T. Gaublomme

    (Harvard University
    Harvard University)

  • Nikolaus Obholzer

    (Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital)

  • James Kozubek

    (Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital)

  • Nathalie Pochet

    (Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Brigham and Women’s Hospital
    Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard)

  • Ana M. C. Faria

    (Institute of Biological Sciences, Federal University of Minas Gerais)

  • Howard L. Weiner

    (Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

Abstract

γδ T cells are a subset of lymphocytes specialized in protecting the host against pathogens and tumours. Here we describe a subset of regulatory γδ T cells that express the latency-associated peptide (LAP), a membrane-bound TGF-β1. Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer’s patches and small intestine lamina propria, where they upregulate LAP, downregulate IFN-γ via ATF-3 expression and acquire a regulatory phenotype. TCRγδ+LAP+ cells express antigen presentation molecules and function as antigen presenting cells that induce CD4+Foxp3+ regulatory T cells, although TCRγδ+LAP+ cells do not themselves express Foxp3. Identification of TCRγδ+LAP+ regulatory cells provides an avenue for understanding immune regulation and biologic processes linked to intestinal function and disease.

Suggested Citation

  • Rafael M. Rezende & Andre P. da Cunha & Chantal Kuhn & Stephen Rubino & Hanane M’Hamdi & Galina Gabriely & Tyler Vandeventer & Shirong Liu & Ron Cialic & Natalia Pinheiro-Rosa & Rafael P. Oliveira & J, 2015. "Identification and characterization of latency-associated peptide-expressing γδ T cells," Nature Communications, Nature, vol. 6(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9726
    DOI: 10.1038/ncomms9726
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    Cited by:

    1. Hadi Abou-El-Hassan & Rafael M. Rezende & Saef Izzy & Galina Gabriely & Taha Yahya & Bruna K. Tatematsu & Karl J. Habashy & Juliana R. Lopes & Gislane L. V. Oliveira & Amir-Hadi Maghzi & Zhuoran Yin &, 2023. "Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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