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Embryo-scale tissue mechanics during Drosophila gastrulation movements

Author

Listed:
  • Matteo Rauzi

    (European Molecular Biology Laboratory Heidelberg)

  • Uros Krzic

    (European Molecular Biology Laboratory Heidelberg)

  • Timothy E. Saunders

    (European Molecular Biology Laboratory Heidelberg)

  • Matej Krajnc

    (Jožef Stefan Institute)

  • Primož Ziherl

    (Jožef Stefan Institute
    Faculty of Mathematics and Physics, University of Ljubljana
    Erwin Schrödinger International Institute for Mathematical Physics, University of Vienna)

  • Lars Hufnagel

    (European Molecular Biology Laboratory Heidelberg)

  • Maria Leptin

    (European Molecular Biology Laboratory Heidelberg)

Abstract

Morphogenesis of an organism requires the development of its parts to be coordinated in time and space. While past studies concentrated on defined cell populations, a synthetic view of the coordination of these events in a whole organism is needed for a full understanding. Drosophila gastrulation begins with the embryo forming a ventral furrow, which is eventually internalized. It is not understood how the rest of the embryo participates in this process. Here we use multiview selective plane illumination microscopy coupled with infrared laser manipulation and mutant analysis to dissect embryo-scale cell interactions during early gastrulation. Lateral cells have a denser medial–apical actomyosin network and shift ventrally as a compact cohort, whereas dorsal cells become stretched. We show that the behaviour of these cells affects furrow internalization. A computational model predicts different mechanical properties associated with tissue behaviour: lateral cells are stiff, whereas dorsal cells are soft. Experimental analysis confirms these properties in vivo.

Suggested Citation

  • Matteo Rauzi & Uros Krzic & Timothy E. Saunders & Matej Krajnc & Primož Ziherl & Lars Hufnagel & Maria Leptin, 2015. "Embryo-scale tissue mechanics during Drosophila gastrulation movements," Nature Communications, Nature, vol. 6(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9677
    DOI: 10.1038/ncomms9677
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    Cited by:

    1. Hannah J. Gustafson & Nikolas Claussen & Stefano Renzis & Sebastian J. Streichan, 2022. "Patterned mechanical feedback establishes a global myosin gradient," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Aurélien Villedieu & Lale Alpar & Isabelle Gaugué & Amina Joudat & François Graner & Floris Bosveld & Yohanns Bellaïche, 2023. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Julien Fierling & Alphy John & Barthélémy Delorme & Alexandre Torzynski & Guy B. Blanchard & Claire M. Lye & Anna Popkova & Grégoire Malandain & Bénédicte Sanson & Jocelyn Étienne & Philippe Marmottan, 2022. "Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Christophe Royer & Elizabeth Sandham & Elizabeth Slee & Falk Schneider & Christoffer B. Lagerholm & Jonathan Godwin & Nisha Veits & Holly Hathrell & Felix Zhou & Karolis Leonavicius & Jemma Garratt & , 2022. "ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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