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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Author

Listed:
  • María Soler Artigas

    (Genetic Epidemiology Group, University of Leicester)

  • Louise V. Wain

    (Genetic Epidemiology Group, University of Leicester)

  • Suzanne Miller

    (Queen’s Medical Centre, University of Nottingham)

  • Abdul Kader Kheirallah

    (Queen’s Medical Centre, University of Nottingham)

  • Jennifer E. Huffman

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Ioanna Ntalla

    (Genetic Epidemiology Group, University of Leicester)

  • Nick Shrine

    (Genetic Epidemiology Group, University of Leicester)

  • Ma’en Obeidat

    (University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital)

  • Holly Trochet

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
    Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee)

  • Wendy L. McArdle

    (School of Social and Community Medicine, University of Bristol)

  • Alexessander Couto Alves

    (MRC -PHE Centre for Environment & Health, School of Public Health, Imperial College London)

  • Jennie Hui

    (Busselton Population Medical Research Institute
    PathWest Laboratory Medicine WA, Sir Charles Gairdner Hospital
    School of Population Health, The University of Western Australia
    School of Pathology and Laboratory Medicine, The University of Western Australia)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Peter K. Joshi

    (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Alexander Teumer

    (University Medicine Greifswald, Community Medicine, SHIP—Clinical Epidemiological Research
    Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Eva Albrecht

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health)

  • Medea Imboden

    (Swiss Tropical and Public Health Institute
    University of Basel)

  • Rajesh Rawal

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München German Research Center for Environmental Health)

  • Lorna M. Lopez

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    University of Edinburgh)

  • Jonathan Marten

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Stefan Enroth

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University)

  • Ida Surakka

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    The National Institute for Health and Welfare (THL))

  • Ozren Polasek

    (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
    Faculty of Medicine, University of Split)

  • Leo-Pekka Lyytikäinen

    (Fimlab Laboratories
    University of Tampere School of Medicine)

  • Raquel Granell

    (School of Social and Community Medicine, University of Bristol)

  • Pirro G. Hysi

    (King's College London)

  • Claudia Flexeder

    (Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • John Beilby

    (Busselton Population Medical Research Institute
    PathWest Laboratory Medicine WA, Sir Charles Gairdner Hospital
    School of Pathology and Laboratory Medicine, The University of Western Australia)

  • Yohan Bossé

    (Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University)

  • Corry-Anke Brandsma

    (University of Groningen, University Medical Center Groningen)

  • Harry Campbell

    (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Christian Gieger

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München German Research Center for Environmental Health)

  • Sven Gläser

    (Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald)

  • Juan R. González

    (Centre for Research in Environmental Epidemiology (CREAL)
    CIBER Epidemiología y Salud Pública (CIBERESP)
    Pompeu Fabra University (UPF))

  • Harald Grallert

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Chris J. Hammond

    (King's College London)

  • Sarah E. Harris

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    Centre for Genomic and Experimental Medicine, University of Edinburgh)

  • Anna-Liisa Hartikainen

    (Department of Obstetrics and Gynecology of Oulu University Hospital ,MRC of Oulu University)

  • Markku Heliövaara

    (The National Institute for Health and Welfare (THL))

  • John Henderson

    (School of Social and Community Medicine, University of Bristol)

  • Lynne Hocking

    (Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee
    University of Aberdeen)

  • Momoko Horikoshi

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford)

  • Nina Hutri-Kähönen

    (Tampere University Hospital
    University of Tampere School of Medicine)

  • Erik Ingelsson

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Molecular Epidemiology and Science for Life Laboratory, Uppsala University
    Stanford University School of Medicine)

  • Åsa Johansson

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
    Uppsala Clinical Research Centre, Uppsala University)

  • John P. Kemp

    (School of Social and Community Medicine, University of Bristol
    Diamantina Institute, Translational Research Institute, University of Queensland
    MRC Integrative Epidemiology Unit)

  • Ivana Kolcic

    (Faculty of Medicine, University of Split)

  • Ashish Kumar

    (Swiss Tropical and Public Health Institute
    University of Basel
    Wellcome Trust Centre for Human Genetics, University of Oxford
    Institute of Environmental Medicine, Karolinska Institutet)

  • Lars Lind

    (Uppsala University)

  • Erik Melén

    (Institute of Environmental Medicine, Karolinska Institutet and Sachs’ Children’s Hospital)

  • Arthur W. Musk

    (Busselton Population Medical Research Institute
    Sir Charles Gairdner Hospital
    School of Medicine and Pharmacology, The University of Western Australia)

  • Pau Navarro

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • David C. Nickle

    (Genetics and Pharmacogenomics, Merck Research Labs)

  • Sandosh Padmanabhan

    (Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee
    University of Glasgow)

  • Olli T. Raitakari

    (Turku University Hospital
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku)

  • Janina S. Ried

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health)

  • Samuli Ripatti

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    University of Helsinki
    Wellcome Trust Sanger Institute)

  • Holger Schulz

    (Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
    Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Don D. Sin

    (University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital
    University of British Columbia)

  • John M. Starr

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    Alzheimer Scotland Research Centre, University of Edinburgh)

  • Ana Viñuela

    (King's College London)

  • Henry Völzke

    (University Medicine Greifswald, Community Medicine, SHIP—Clinical Epidemiological Research)

  • Sarah H. Wild

    (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Alan F. Wright

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Tatijana Zemunik

    (Faculty of Medicine, University of Split)

  • Deborah L. Jarvis

    (Respiratory Epidemiology and Public Health, Imperial College London
    MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London)

  • Tim D. Spector

    (King's College London)

  • David M. Evans

    (School of Social and Community Medicine, University of Bristol
    Diamantina Institute, Translational Research Institute, University of Queensland
    MRC Integrative Epidemiology Unit)

  • Terho Lehtimäki

    (Fimlab Laboratories
    University of Tampere School of Medicine)

  • Veronique Vitart

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Mika Kähönen

    (University of Tampere and Tampere University Hospital)

  • Ulf Gyllensten

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University)

  • Igor Rudan

    (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
    Centre for Population Health Sciences, Medical School, University of Edinburgh)

  • Ian J. Deary

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    University of Edinburgh)

  • Stefan Karrasch

    (Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of General Practice, University Hospital Klinikum rechts der Isar, Technische Universität München
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität)

  • Nicole M. Probst-Hensch

    (Swiss Tropical and Public Health Institute
    University of Basel)

  • Joachim Heinrich

    (Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health
    Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research
    University Hospital Munich, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilian University Munich)

  • Beate Stubbe

    (Pneumology, Cardiology, Intensive Care, Weaning, Field of Research: Pneumological Epidemiology, University Medicine Greifswald)

  • James F. Wilson

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
    Usher Institute of Population Health Sciences and Informatics, University of Edinburgh)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus)

  • Alan L. James

    (Busselton Population Medical Research Institute
    School of Medicine and Pharmacology, The University of Western Australia
    Sir Charles Gairdner Hospital)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Liverpool
    Estonian Genome Centre, University of Tartu)

  • Marjo-Riitta Jarvelin

    (MRC -PHE Centre for Environment & Health, School of Public Health, Imperial College London
    Center for Life Course Epidemiology, Faculty of Medicine, P.O.Box 5000, FI-90014 University of Oulu
    Biocenter Oulu, P.O.Box 5000, Aapistie 5A, FI-90014 University of Oulu
    Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20)

  • Caroline Hayward

    (Generation Scotland, A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee)

  • Ian Sayers

    (Queen’s Medical Centre, University of Nottingham)

  • David P. Strachan

    (Population Health Research Institute, St George’s, University of London)

  • Ian P. Hall

    (Queen’s Medical Centre, University of Nottingham)

  • Martin D. Tobin

    (Genetic Epidemiology Group, University of Leicester
    National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital)

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

Suggested Citation

  • María Soler Artigas & Louise V. Wain & Suzanne Miller & Abdul Kader Kheirallah & Jennifer E. Huffman & Ioanna Ntalla & Nick Shrine & Ma’en Obeidat & Holly Trochet & Wendy L. McArdle & Alexessander Cou, 2015. "Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation," Nature Communications, Nature, vol. 6(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9658
    DOI: 10.1038/ncomms9658
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