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Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato

Author

Listed:
  • Yang Zhang

    (John Innes Centre, Norwich Research Park)

  • Eugenio Butelli

    (John Innes Centre, Norwich Research Park)

  • Saleh Alseekh

    (Max-Planck-Institute of Molecular Plant Physiology)

  • Takayuki Tohge

    (Max-Planck-Institute of Molecular Plant Physiology)

  • Ghanasyam Rallapalli

    (The Sainsbury Laboratory, Norwich Research Park, Colney)

  • Jie Luo

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Prashant G. Kawar

    (Indian Council of Agricultural Research – Central Potato Research Institute)

  • Lionel Hill

    (John Innes Centre, Norwich Research Park)

  • Angelo Santino

    (Institute of Sciences of Food Production C.N.R. Unit of Lecce)

  • Alisdair R. Fernie

    (Max-Planck-Institute of Molecular Plant Physiology)

  • Cathie Martin

    (John Innes Centre, Norwich Research Park)

Abstract

Phenylpropanoids comprise an important class of plant secondary metabolites. A number of transcription factors have been used to upregulate-specific branches of phenylpropanoid metabolism, but by far the most effective has been the fruit-specific expression of AtMYB12 in tomato, which resulted in as much as 10% of fruit dry weight accumulating as flavonols and hydroxycinnamates. We show that AtMYB12 not only increases the demand of flavonoid biosynthesis but also increases the supply of carbon from primary metabolism, energy and reducing power, which may fuel the shikimate and phenylalanine biosynthetic pathways to supply more aromatic amino acids for secondary metabolism. AtMYB12 directly binds promoters of genes encoding enzymes of primary metabolism. The enhanced supply of precursors, energy and reducing power achieved by AtMYB12 expression can be harnessed to engineer high levels of novel phenylpropanoids in tomato fruit, offering an effective production system for bioactives and other high value ingredients.

Suggested Citation

  • Yang Zhang & Eugenio Butelli & Saleh Alseekh & Takayuki Tohge & Ghanasyam Rallapalli & Jie Luo & Prashant G. Kawar & Lionel Hill & Angelo Santino & Alisdair R. Fernie & Cathie Martin, 2015. "Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9635
    DOI: 10.1038/ncomms9635
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    1. Guy Polturak & Rajesh Chandra Misra & Amr El-Demerdash & Charlotte Owen & Andrew Steed & Hannah P. McDonald & JiaoJiao Wang & Gerhard Saalbach & Carlo Martins & Laetitia Chartrain & Barrie Wilkinson &, 2023. "Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Feng Bai & Peng Shu & Heng Deng & Yi Wu & Yao Chen & Mengbo Wu & Tao Ma & Yang Zhang & Julien Pirrello & Zhengguo Li & Yiguo Hong & Mondher Bouzayen & Mingchun Liu, 2024. "A distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Virgínia Carvalho Lemos & Julia Jessica Reimer & Alexandra Wormit, 2019. "Color for Life: Biosynthesis and Distribution of Phenolic Compounds in Pepper ( Capsicum annuum )," Agriculture, MDPI, vol. 9(4), pages 1-29, April.

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