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Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway

Author

Listed:
  • Franziska Bender

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Maria Gorbati

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Marta Carus Cadavieco

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Natalia Denisova

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Xiaojie Gao

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Constance Holman

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Tatiana Korotkova

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

  • Alexey Ponomarenko

    (Behavioural Neurodynamics Group, Leibniz-Institut für Molekulare Pharmakologie (FMP)
    NeuroCure Cluster of Excellence, Charité Universitätsmedizin)

Abstract

Hippocampal theta oscillations support encoding of an animal’s position during spatial navigation, yet longstanding questions about their impact on locomotion remain unanswered. Combining optogenetic control of hippocampal theta oscillations with electrophysiological recordings in mice, we show that hippocampal theta oscillations regulate locomotion. In particular, we demonstrate that their regularity underlies more stable and slower running speeds during exploration. More regular theta oscillations are accompanied by more regular theta-rhythmic spiking output of pyramidal cells. Theta oscillations are coordinated between the hippocampus and its main subcortical output, the lateral septum (LS). Chemo- or optogenetic inhibition of this pathway reveals its necessity for the hippocampal regulation of running speed. Moreover, theta-rhythmic stimulation of LS projections to the lateral hypothalamus replicates the reduction of running speed induced by more regular hippocampal theta oscillations. These results suggest that changes in hippocampal theta synchronization are translated into rapid adjustment of running speed via the LS.

Suggested Citation

  • Franziska Bender & Maria Gorbati & Marta Carus Cadavieco & Natalia Denisova & Xiaojie Gao & Constance Holman & Tatiana Korotkova & Alexey Ponomarenko, 2015. "Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9521
    DOI: 10.1038/ncomms9521
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    Cited by:

    1. Guillaume Etter & Suzanne Veldt & Jisoo Choi & Sylvain Williams, 2023. "Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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