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Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer

Author

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  • Meilin Wang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
    Center for Cancer Genomics, Wake Forest University School of Medicine)

  • Atsushi Takahashi

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • Fang Liu

    (Fudan Institute of Urology, Huashan Hospital, Fudan University)

  • Dingwei Ye

    (Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University)

  • Qiang Ding

    (Fudan Institute of Urology, Huashan Hospital, Fudan University)

  • Chao Qin

    (The First Affiliated Hospital of Nanjing Medical University)

  • Changjun Yin

    (The First Affiliated Hospital of Nanjing Medical University)

  • Zhengdong Zhang

    (Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University)

  • Koichi Matsuda

    (Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo)

  • Michiaki Kubo

    (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences)

  • Rong Na

    (Fudan Institute of Urology, Huashan Hospital, Fudan University)

  • Xiaoling Lin

    (Fudan Institute of Urology, Huashan Hospital, Fudan University)

  • Haowen Jiang

    (Fudan Institute of Urology, Huashan Hospital, Fudan University)

  • Shancheng Ren

    (Shanghai Changhai Hospital, Second Military Medical University)

  • Jielin Sun

    (Center for Cancer Genomics, Wake Forest University School of Medicine)

  • S. Lilly Zheng

    (Center for Cancer Genomics, Wake Forest University School of Medicine
    Program for Personalized Cancer Care, NorthShore University HealthSystem)

  • Loic Le Marchand

    (University of Hawaii Cancer Center)

  • William B. Isaacs

    (James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine)

  • Zengnan Mo

    (Center for Genomic and Personalized Medicine, Guangxi Medical University)

  • Christopher A. Haiman

    (Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Yinghao Sun

    (Shanghai Changhai Hospital, Second Military Medical University)

  • Hidewaki Nakagawa

    (Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences)

  • Jianfeng Xu

    (Fudan Institute of Urology, Huashan Hospital, Fudan University
    Program for Personalized Cancer Care, NorthShore University HealthSystem)

Abstract

Genome-wide association studies (GWAS) have identified ∼100 genetic loci associated with prostate cancer risk. Less than a dozen of these loci were initially identified from GWAS in two Asian populations, likely because of smaller sample sizes of these individual GWAS in Asians. Here, we conduct a large-scale meta-analysis of two GWAS from the Japanese population (1,583 cases and 3,386 controls) and the Chinese population (1,417 cases and 1,008 controls), followed by replication in three independent sample sets. We identify two independent susceptibility loci for prostate cancer at 11p15.4 (rs12791447, P=3.59 × 10−8; PPFIBP2) and 14q23.2 (rs58262369, P=6.05 × 10−10; ESR2). The mRNA levels of PPFIBP2 and ESR2 are differentially expressed in prostate tumours and paired normal tissues. Our study adds two new loci to the limited number of prostate cancer risk-associated variants in Asians and provides important insight into potential biological mechanisms of prostate cancer.

Suggested Citation

  • Meilin Wang & Atsushi Takahashi & Fang Liu & Dingwei Ye & Qiang Ding & Chao Qin & Changjun Yin & Zhengdong Zhang & Koichi Matsuda & Michiaki Kubo & Rong Na & Xiaoling Lin & Haowen Jiang & Shancheng Re, 2015. "Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9469
    DOI: 10.1038/ncomms9469
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    Cited by:

    1. Shuji Ito & Xiaoxi Liu & Yuki Ishikawa & David D. Conti & Nao Otomo & Zsofia Kote-Jarai & Hiroyuki Suetsugu & Rosalind A. Eeles & Yoshinao Koike & Keiko Hikino & Soichiro Yoshino & Kohei Tomizuka & Mo, 2023. "Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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