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PTEN regulates cilia through Dishevelled

Author

Listed:
  • Iryna Shnitsar

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Mikhail Bashkurov

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Glenn R. Masson

    (Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus)

  • Abiodun A. Ogunjimi

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Sherly Mosessian

    (University of California)

  • Eduardo Aguiar Cabeza

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Calley L. Hirsch

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Daniel Trcka

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Gerald Gish

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Jing Jiao

    (University of California)

  • Hong Wu

    (University of California)

  • Rudolf Winklbauer

    (University of Toronto)

  • Roger L. Williams

    (Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus)

  • Laurence Pelletier

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    University of Toronto)

  • Jeffrey L. Wrana

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    University of Toronto)

  • Miriam Barrios-Rodiles

    (Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

Abstract

Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial surfaces, while primary (sensory) cilia play roles in cellular signalling. The molecular events underlying cilia dynamics, and particularly their disassembly, are not well understood. Phosphatase and tensin homologue (PTEN) is an extensively studied tumour suppressor, thought to primarily act by antagonizing PI3-kinase signalling. Here we demonstrate that PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (DVL), another ciliogenesis regulator. DVL is a central component of WNT signalling that plays a role during convergent extension movements, which we show here are also regulated by PTEN. Our studies identify a novel protein substrate for PTEN that couples PTEN to regulation of cilia dynamics and WNT signalling, thus advancing our understanding of potential underlying molecular etiologies of PTEN-related pathologies.

Suggested Citation

  • Iryna Shnitsar & Mikhail Bashkurov & Glenn R. Masson & Abiodun A. Ogunjimi & Sherly Mosessian & Eduardo Aguiar Cabeza & Calley L. Hirsch & Daniel Trcka & Gerald Gish & Jing Jiao & Hong Wu & Rudolf Win, 2015. "PTEN regulates cilia through Dishevelled," Nature Communications, Nature, vol. 6(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9388
    DOI: 10.1038/ncomms9388
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    Cited by:

    1. Melati S. Abdul Halim & Jennifer M. Dyson & Max M. Gong & Moira K. O’Bryan & Reza Nosrati, 2024. "Fallopian tube rheology regulates epithelial cell differentiation and function to enhance cilia formation and coordination," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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