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Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system

Author

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  • Ken-ichi Inoue

    (Systems Neuroscience Section, Primate Research Institute, Kyoto University)

  • Masahiko Takada

    (Systems Neuroscience Section, Primate Research Institute, Kyoto University)

  • Masayuki Matsumoto

    (Systems Neuroscience Section, Primate Research Institute, Kyoto University
    Faculty of Medicine, University of Tsukuba)

Abstract

Optogenetics enables temporally and spatially precise control of neuronal activity in vivo. One of the key advantages of optogenetics is that it can be used to control the activity of targeted neural pathways that connect specific brain regions. While such pathway-selective optogenetic control is a popular tool in rodents, attempts at modulating behaviour using pathway-selective optogenetics have not yet been successful in primates. Here we develop a methodology for pathway-selective optogenetics in macaque monkeys, focusing on the pathway from the frontal eye field (FEF) to the superior colliculus (SC), part of the complex oculomotor network. We find that the optogenetic stimulation of FEF projections to the SC modulates SC neuron activity and is sufficient to evoke saccadic eye movements towards the response field corresponding to the stimulation site. Thus, our results demonstrate the feasibility of using pathway-selective optogenetics to elucidate neural network function in primates.

Suggested Citation

  • Ken-ichi Inoue & Masahiko Takada & Masayuki Matsumoto, 2015. "Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9378
    DOI: 10.1038/ncomms9378
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    Cited by:

    1. Kei Kimura & Yuji Nagai & Gaku Hatanaka & Yang Fang & Soshi Tanabe & Andi Zheng & Maki Fujiwara & Mayuko Nakano & Yukiko Hori & Ryosuke F. Takeuchi & Mikio Inagaki & Takafumi Minamimoto & Ichiro Fujit, 2023. "A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Kazutaka Maeda & Ken-ichi Inoue & Masahiko Takada & Okihide Hikosaka, 2023. "Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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