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NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

Author

Listed:
  • Paolo Carrega

    (Istituto G. Gaslini)

  • Fabrizio Loiacono

    (Istituto G. Gaslini)

  • Emma Di Carlo

    (‘G. d'Annunzio’ University
    Centro di Scienze dell’Invecchiamento, Fondazione Università ‘G. d’Annunzio’)

  • Angelo Scaramuccia

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro)

  • Marco Mora

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro)

  • Romana Conte

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro)

  • Roberto Benelli

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro)

  • Grazia Maria Spaggiari

    (University of Genova)

  • Claudia Cantoni

    (Istituto G. Gaslini
    University of Genova
    Center of Excellence in Biomedical Research, Centro di Eccellenza per la Ricerca Biomedica (CEBR), University of Genova)

  • Stefania Campana

    (Laboratory of Immunology and Biotherapy, University of Messina)

  • Irene Bonaccorsi

    (Laboratory of Immunology and Biotherapy, University of Messina)

  • Barbara Morandi

    (University of Genova)

  • Mauro Truini

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro)

  • Maria Cristina Mingari

    (Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino/IST-Istituto Nazionale per la Ricerca sul Cancro
    University of Genova
    Center of Excellence in Biomedical Research, Centro di Eccellenza per la Ricerca Biomedica (CEBR), University of Genova)

  • Lorenzo Moretta

    (IRCCS Bambino Gesù Children's Hospital)

  • Guido Ferlazzo

    (Laboratory of Immunology and Biotherapy, University of Messina
    Cell Therapy Program, Azienda Ospedaliera Universitaria Policlinico ‘Gaetano Martino’)

Abstract

Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer (NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate lymphoid cell (ILC)-3 are present in the lymphoid infiltrate of human NSCLC and are mainly localized at the edge of tumour-associated TLSs. This intra-tumoral lymphocyte subset is endowed with lymphoid tissue-inducing properties and, on activation, produces IL-22, TNF-α, IL-8 and IL-2, and activates endothelial cells. Tumour NCR+ILC3 may interact with both lung tumour cells and tumour-associated fibroblasts, resulting in the release of cytokines primarily on engagement of the NKp44-activating receptor. In patients, NCR+ILC3 are present in significantly higher amounts in stage I/II NSCLC than in more advanced tumour stages and their presence correlate with the density of intratumoral TLSs. Our results indicate that NCR+ILC3 accumulate in human NSCLC tissue and might contribute to the formation of protective tumour-associated TLSs.

Suggested Citation

  • Paolo Carrega & Fabrizio Loiacono & Emma Di Carlo & Angelo Scaramuccia & Marco Mora & Romana Conte & Roberto Benelli & Grazia Maria Spaggiari & Claudia Cantoni & Stefania Campana & Irene Bonaccorsi & , 2015. "NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9280
    DOI: 10.1038/ncomms9280
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