IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms9234.html
   My bibliography  Save this article

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Author

Listed:
  • Kate Lawrenson

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Qiyuan Li

    (Medical College, Xiamen University
    The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Siddhartha Kar

    (University of Cambridge, Strangeways Research Laboratory)

  • Ji-Heui Seo

    (The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

  • Jonathan Tyrer

    (University of Cambridge, Strangeways Research Laboratory)

  • Tassja J. Spindler

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Janet Lee

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Yibu Chen

    (Bioinformatics Service, Norris Medical Library, University of Southern California)

  • Alison Karst

    (Dana-Farber Cancer Institute)

  • Ronny Drapkin

    (Dana-Farber Cancer Institute)

  • Katja K. H. Aben

    (Radboud University Medical Centre
    Comprehensive Cancer Center, The Netherlands)

  • Hoda Anton-Culver

    (Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine)

  • Natalia Antonenkova

    (Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N.)

  • Helen Baker

    (University of Cambridge, Strangeways Research Laboratory)

  • Elisa V. Bandera

    (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey)

  • Yukie Bean

    (Oregon Health and Science University
    Knight Cancer Institute, Oregon Health and Science University)

  • Matthias W. Beckmann

    (University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Andrew Berchuck

    (Duke University Medical Center)

  • Maria Bisogna

    (Gynecology Service, Memorial Sloan Kettering Cancer Center)

  • Line Bjorge

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Natalia Bogdanova

    (Gynaecology Research Unit, Hannover Medical School)

  • Louise A. Brinton

    (National Cancer Institute)

  • Angela Brooks-Wilson

    (Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
    Simon Fraser University)

  • Fiona Bruinsma

    (Cancer Epidemiology Centre, Cancer Council Victoria)

  • Ralf Butzow

    (University of Helsinki and Helsinki University Central Hospital
    Helsinki University Central Hospital)

  • Ian G. Campbell

    (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre
    University of Melbourne
    University of Melbourne)

  • Karen Carty

    (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ))

  • Georgia Chenevix-Trench

    (QIMR Berghofer Medical Research Institute)

  • Anne Chen

    (Moffitt Cancer Center)

  • Zhihua Chen

    (Moffitt Cancer Center)

  • Linda S. Cook

    (University of New Mexico)

  • Daniel W. Cramer

    (Harvard School of Public Health
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital and Harvard Medical School)

  • Julie M. Cunningham

    (Mayo Clinic)

  • Cezary Cybulski

    (Pomeranian Medical University)

  • Agnieszka Dansonka-Mieszkowska

    (Pomeranian Medical University)

  • Joe Dennis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Ed Dicks

    (University of Cambridge, Strangeways Research Laboratory)

  • Jennifer A. Doherty

    (The Geisel School of Medicine at Dartmouth)

  • Thilo Dörk

    (Gynaecology Research Unit, Hannover Medical School)

  • Andreas du Bois

    (Kliniken Essen-Mitte
    Dr Horst Schmidt Kliniken Wiesbaden)

  • Matthias Dürst

    (Jena University Hospital—Friedrich Schiller University)

  • Diana Eccles

    (Faculty of Medicine, University of Southampton)

  • Douglas T. Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Robert P. Edwards

    (Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine
    Ovarian Cancer Center of Excellence, University of Pittsburgh)

  • Ursula Eilber

    (German Cancer Research Center (DKFZ))

  • Arif B. Ekici

    (University Hospital Erlangen, Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nuremberg)

  • Peter A. Fasching

    (University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
    David Geffen School of Medicine, University of California at Los Angeles)

  • Brooke L. Fridley

    (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center)

  • Yu-Tang Gao

    (Shanghai Cancer Institute)

  • Aleksandra Gentry-Maharaj

    (Institute for Women’s Health, University College London)

  • Graham G. Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Rosalind Glasspool

    (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre)

  • Ellen L. Goode

    (Mayo Clinic)

  • Marc T. Goodman

    (Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
    Community and Population Health Research Institute, Cedars-Sinai Medical Center)

  • Jacek Grownwald

    (Pomeranian Medical University)

  • Patricia Harrington

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Philipp Harter

    (Kliniken Essen-Mitte
    Dr Horst Schmidt Kliniken Wiesbaden)

  • Hanis Nazihah Hasmad

    (Cancer Research Initiatives Foundation, Sime Darby Medical Centre)

  • Alexander Hein

    (University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN)

  • Florian Heitz

    (Kliniken Essen-Mitte
    Dr Horst Schmidt Kliniken Wiesbaden)

  • Michelle A. T. Hildebrandt

    (The University of Texas MD Anderson Cancer Center)

  • Peter Hillemanns

    (Hannover Medical School)

  • Estrid Hogdall

    (Institute of Cancer Epidemiology, Danish Cancer Society
    Molecular Unit, Herlev Hospital, University of Copenhagen)

  • Claus Hogdall

    (Gyn Clinic, Rigshospitalet, University of Copenhagen)

  • Satoyo Hosono

    (Aichi Cancer Center Research Institute)

  • Edwin S. Iversen

    (Duke University)

  • Anna Jakubowska

    (Pomeranian Medical University)

  • Paul James

    (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre)

  • Allan Jensen

    (Rigshospitalet, University of Copenhagen)

  • Bu-Tian Ji

    (National Cancer Institute)

  • Beth Y. Karlan

    (Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Susanne Kruger Kjaer

    (Lifestyle and Genes, Danish Cancer Society Research Center
    The Juliane Marie Centre, Rigshospitalet, University of Copenhagen)

  • Linda E. Kelemen

    (College of Medicine, Medical University of South Carolina)

  • Melissa Kellar

    (Oregon Health and Science University
    Knight Cancer Institute, Oregon Health and Science University)

  • Joseph L. Kelley

    (Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine)

  • Lambertus A. Kiemeney

    (Radboud University Medical Mentre, Radboud Institute for Health Sciences)

  • Camilla Krakstad

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Jolanta Kupryjanczyk

    (Pomeranian Medical University)

  • Diether Lambrechts

    (Vesalius Research Center, VIB
    Laboratory for Translational Genetics, University of Leuven)

  • Sandrina Lambrechts

    (University Hospitals Leuven)

  • Nhu D. Le

    (Cancer Control Research, BC Cancer Agency)

  • Alice W. Lee

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Shashi Lele

    (Roswell Park Cancer Institute)

  • Arto Leminen

    (University of Helsinki and Helsinki University Central Hospital)

  • Jenny Lester

    (Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Douglas A. Levine

    (Gynecology Service, Memorial Sloan Kettering Cancer Center)

  • Dong Liang

    (College of Pharmacy and Health Sciences, Texas Southern University)

  • Jolanta Lissowska

    (Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology)

  • Karen Lu

    (The University of Texas MD Anderson Cancer Center)

  • Jan Lubinski

    (Pomeranian Medical University)

  • Lene Lundvall

    (Molecular Unit, Herlev Hospital, University of Copenhagen)

  • Leon F. A. G. Massuger

    (Radboud University Medical Centre)

  • Keitaro Matsuo

    (Kyushu University Faculty of Medical Sciences)

  • Valerie McGuire

    (Stanford University School of Medicine)

  • John R. McLaughlin

    (Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Heli Nevanlinna

    (University of Helsinki and Helsinki University Central Hospital)

  • Ian McNeish

    (Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, University of Glasgow)

  • Usha Menon

    (Institute for Women’s Health, University College London)

  • Francesmary Modugno

    (Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine
    Ovarian Cancer Center of Excellence, University of Pittsburgh
    Women’s Cancer Research Program, Magee-Women’s Research Institute and University of Pittsburgh Cancer Institute
    University of Pittsburgh Graduate School of Public Health)

  • Kirsten B. Moysich

    (Roswell Park Cancer Institute)

  • Steven A. Narod

    (Memorial Sloan Kettering Cancer Center)

  • Lotte Nedergaard

    (Rigshospitalet, University of Copenhagen)

  • Roberta B. Ness

    (The University of Texas School of Public Health)

  • Mat Adenan Noor Azmi

    (University Malaya Medical Centre, University Malaya)

  • Kunle Odunsi

    (Roswell Park Cancer Institute)

  • Sara H. Olson

    (Memorial Sloan Kettering Cancer Center)

  • Irene Orlow

    (Memorial Sloan Kettering Cancer Center)

  • Sandra Orsulic

    (Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Rachel Palmieri Weber

    (Duke University Medical Center)

  • Celeste L. Pearce

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Tanja Pejovic

    (Oregon Health and Science University
    Knight Cancer Institute, Oregon Health and Science University)

  • Liisa M. Pelttari

    (University of Helsinki and Helsinki University Central Hospital)

  • Jennifer Permuth-Wey

    (Moffitt Cancer Center)

  • Catherine M. Phelan

    (Moffitt Cancer Center)

  • Malcolm C. Pike

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
    Brigham and Women’s Hospital and Harvard Medical School)

  • Elizabeth M. Poole

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • Susan J. Ramus

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Harvey A. Risch

    (Yale School of Public Health)

  • Barry Rosen

    (Princess Margaret Hospital, Faculty of Medicine, University of Toronto)

  • Mary Anne Rossing

    (Program in Epidemiology, Fred Hutchinson Cancer Research Center
    University of Washington)

  • Joseph H. Rothstein

    (Stanford University School of Medicine)

  • Anja Rudolph

    (German Cancer Research Center (DKFZ))

  • Ingo B. Runnebaum

    (Jena University Hospital—Friedrich Schiller University)

  • Iwona K. Rzepecka

    (Pomeranian Medical University)

  • Helga B. Salvesen

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Joellen M. Schildkraut

    (Cancer Control and Population Sciences, Duke Cancer Institute
    Institut für Humangenetik Wiesbaden)

  • Ira Schwaab

    (Institut für Humangenetik Wiesbaden)

  • Thomas A. Sellers

    (Moffitt Cancer Center)

  • Xiao-Ou Shu

    (Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Yurii B. Shvetsov

    (Cancer Epidemiology Program, University of Hawaii Cancer Center)

  • Nadeem Siddiqui

    (Glasgow Royal Infirmary)

  • Weiva Sieh

    (Stanford University School of Medicine)

  • Honglin Song

    (University of Cambridge, Strangeways Research Laboratory)

  • Melissa C. Southey

    (University of Melbourne)

  • Lara Sucheston

    (Roswell Park Cancer Institute)

  • Ingvild L. Tangen

    (Haukeland University Hospital
    Centre for Cancer Biomarkers, University of Bergen)

  • Soo-Hwang Teo

    (Cancer Research Initiatives Foundation, Sime Darby Medical Centre
    University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya)

  • Kathryn L. Terry

    (University of New Mexico
    Harvard School of Public Health)

  • Pamela J. Thompson

    (Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
    Community and Population Health Research Institute, Cedars-Sinai Medical Center)

  • Agnieszka Timorek

    (Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital)

  • Ya-Yu Tsai

    (Moffitt Cancer Center)

  • Shelley S. Tworoger

    (Brigham and Women’s Hospital and Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • Anne M. van Altena

    (Radboud University Medical Centre)

  • Els Van Nieuwenhuysen

    (University Hospitals Leuven)

  • Ignace Vergote

    (University Hospitals Leuven)

  • Robert A. Vierkant

    (Mayo Clinic)

  • Shan Wang-Gohrke

    (University of Ulm)

  • Christine Walsh

    (Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center)

  • Nicolas Wentzensen

    (National Cancer Institute)

  • Alice S. Whittemore

    (Stanford University School of Medicine)

  • Kristine G. Wicklund

    (Program in Epidemiology, Fred Hutchinson Cancer Research Center)

  • Lynne R. Wilkens

    (Cancer Epidemiology Program, University of Hawaii Cancer Center)

  • Yin-Ling Woo

    (University Malaya Medical Centre, University Malaya
    University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya)

  • Xifeng Wu

    (The University of Texas MD Anderson Cancer Center)

  • Anna H. Wu

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Hannah Yang

    (National Cancer Institute)

  • Wei Zheng

    (Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Argyrios Ziogas

    (Director of Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine)

  • Alvaro Monteiro

    (Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute)

  • Paul D. Pharoah

    (University of Cambridge, Strangeways Research Laboratory)

  • Simon A. Gayther

    (Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center)

  • Matthew L. Freedman

    (The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute)

Abstract

Genome-wide association studies have reported 11 regions conferring risk of high-grade serous epithelial ovarian cancer (HGSOC). Expression quantitative trait locus (eQTL) analyses can identify candidate susceptibility genes at risk loci. Here we evaluate cis-eQTL associations at 47 regions associated with HGSOC risk (P≤10−5). For three cis-eQTL associations (P

Suggested Citation

  • Kate Lawrenson & Qiyuan Li & Siddhartha Kar & Ji-Heui Seo & Jonathan Tyrer & Tassja J. Spindler & Janet Lee & Yibu Chen & Alison Karst & Ronny Drapkin & Katja K. H. Aben & Hoda Anton-Culver & Natalia , 2015. "Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer," Nature Communications, Nature, vol. 6(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9234
    DOI: 10.1038/ncomms9234
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms9234
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms9234?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qian Xiao & Joseph Mears & Aparna Nathan & Kazuyoshi Ishigaki & Yuriy Baglaenko & Noha Lim & Laura A. Cooney & Kristina M. Harris & Mark S. Anderson & David A. Fox & Dawn E. Smilek & James G. Krueger , 2023. "Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9234. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.