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Telomere maintenance through recruitment of internal genomic regions

Author

Listed:
  • Beomseok Seo

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Chuna Kim

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Mark Hills

    (Terry Fox Laboratory, BC Cancer Agency)

  • Sanghyun Sung

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Hyesook Kim

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Eunkyeong Kim

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Daisy S. Lim

    (Institute of Molecular Biology and Genetics, Seoul National University)

  • Hyun-Seok Oh

    (Bioinformatics Institute, BIO-MAX, Seoul National University)

  • Rachael Mi Jung Choi

    (Bioinformatics Institute, BIO-MAX, Seoul National University)

  • Jongsik Chun

    (Bioinformatics Institute, BIO-MAX, Seoul National University)

  • Jaegal Shim

    (Research Institute, National Cancer Center)

  • Junho Lee

    (Institute of Molecular Biology and Genetics, Seoul National University
    Seoul National University)

Abstract

Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. However, surviving cells occasionally activate a recombination-based mechanism called alternative lengthening of telomeres (ALT). Here we establish stably maintained survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT survivors trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across the telomeres of all chromosomes. These ‘Template for ALT’ (TALT) regions consist of a block of genomic DNA flanked by telomere-like sequences, and are different between two genetic background. We establish a model that an ancestral duplication of a donor TALT region to a proximal telomere region forms a genomic reservoir ready to be incorporated into telomeres on ALT activation.

Suggested Citation

  • Beomseok Seo & Chuna Kim & Mark Hills & Sanghyun Sung & Hyesook Kim & Eunkyeong Kim & Daisy S. Lim & Hyun-Seok Oh & Rachael Mi Jung Choi & Jongsik Chun & Jaegal Shim & Junho Lee, 2015. "Telomere maintenance through recruitment of internal genomic regions," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9189
    DOI: 10.1038/ncomms9189
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