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Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex

Author

Listed:
  • Margaret L. Schlichting

    (Center for Learning and Memory, The University of Texas at Austin
    The University of Texas at Austin)

  • Jeanette A. Mumford

    (Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison)

  • Alison R. Preston

    (Center for Learning and Memory, The University of Texas at Austin
    The University of Texas at Austin
    The University of Texas at Austin)

Abstract

The episodic memory system enables accurate retrieval while maintaining flexibility by representing both specific episodes and generalizations across events. Although theories suggest that the hippocampus (HPC) is dedicated to represent specific episodes while the medial prefrontal cortex (MPFC) generalizes, other accounts posit that HPC can also integrate related memories. Here we use high-resolution functional magnetic resonance imaging in humans to examine how representations of memory elements change to either differentiate or generalize across related events. We show that while posterior HPC and anterior MPFC maintain distinct memories for individual events, anterior HPC and posterior MPFC integrate across memories. Integration is particularly likely for established memories versus those encoded simultaneously, highlighting the greater impact of prior knowledge on new encoding. We also show dissociable coding signatures in ventrolateral PFC, a region previously implicated in interference resolution. These data highlight how memory elements are represented to simultaneously promote generalization across memories and protect from interference.

Suggested Citation

  • Margaret L. Schlichting & Jeanette A. Mumford & Alison R. Preston, 2015. "Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9151
    DOI: 10.1038/ncomms9151
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    Cited by:

    1. Zachariah M. Reagh & Charan Ranganath, 2023. "Flexible reuse of cortico-hippocampal representations during encoding and recall of naturalistic events," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Jacob L. S. Bellmund & Lorena Deuker & Nicole D. Montijn & Christian F. Doeller, 2022. "Mnemonic construction and representation of temporal structure in the hippocampal formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Nir Moneta & Mona M. Garvert & Hauke R. Heekeren & Nicolas W. Schuck, 2023. "Task state representations in vmPFC mediate relevant and irrelevant value signals and their behavioral influence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Li Zheng & Zhiyao Gao & Andrew S. McAvan & Eve A. Isham & Arne D. Ekstrom, 2021. "Partially overlapping spatial environments trigger reinstatement in hippocampus and schema representations in prefrontal cortex," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    6. Sam Audrain & Mary Pat McAndrews, 2022. "Schemas provide a scaffold for neocortical integration of new memories over time," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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