IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms9109.html
   My bibliography  Save this article

‘Emergency exit’ of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation

Author

Listed:
  • Federica Bozzano

    (University of Genova
    Center for Excellence in Biomedical Research, University of Genova)

  • Francesco Marras

    (Istituto Giannina Gaslini)

  • Maria Libera Ascierto

    (Clinical Center and Center of Human Immunology, National Institutes of Health
    Johns Hopkins University)

  • Claudia Cantoni

    (University of Genova
    Center for Excellence in Biomedical Research, University of Genova
    Istituto Giannina Gaslini)

  • Giovanni Cenderello

    (U.O.C. Malattie Infettive, Ospedale Galliera)

  • Chiara Dentone

    (U.O.C. Malattie Infettive, Ospedale Sanremo)

  • Antonio Di Biagio

    (Clinica Malattie Infettive, IRCCS AOU San Martino-IST Genova, Istituto Nazionale per la Ricerca sul Cancro)

  • Giancarlo Orofino

    (SOC Malattie Infettive ASO S.S. Antonio e Biagio e C. Arrigo Alessandria)

  • Eugenio Mantia

    (U.O.C. Malattie Infettive, Ospedale Amedeo di Savoia)

  • Silvia Boni

    (U.O.C. Malattie Infettive, Ospedale Sant’Andrea)

  • Pasqualina De Leo

    (U.O.C. Malattie Infettive, Azienda Sanitaria Locale n.2)

  • Antonino Picciotto

    (Allergy and Respiratory Unit, University of Genova)

  • Fulvio Braido

    (Hepatology Unit, University of Genova)

  • Francesca Antonini

    (Istituto Giannina Gaslini)

  • Ena Wang

    (Clinical Center and Center of Human Immunology, National Institutes of Health
    Sidra Medical and Research Centre)

  • Francesco Marincola

    (Sidra Medical and Research Centre)

  • Lorenzo Moretta

    (Istituto Giannina Gaslini)

  • Andrea De Maria

    (Center for Excellence in Biomedical Research, University of Genova
    Clinica Malattie Infettive, IRCCS AOU San Martino-IST Genova, Istituto Nazionale per la Ricerca sul Cancro
    DISSAL, University of Genova)

Abstract

During chronic inflammatory disorders, a persistent natural killer (NK) cell derangement is observed. While increased cell turnover is expected, little is known about whether and how NK-cell homeostatic balance is maintained. Here, flow cytometric analysis of peripheral blood mononuclear cells in chronic inflammatory disorders, both infectious and non-infectious, reveals the presence of a CD34+CD226(DNAM-1)brightCXCR4+ cell population displaying transcriptional signatures typical of common lymphocyte precursors and giving rise to NK-cell progenies with high expression of activating receptors and mature function and even to α/β T lymphocytes. CD34+CD226brightCXCR4+ cells reside in bone marrow, hardly circulate in healthy donors and are absent in cord blood. Their proportion correlates with the degree of inflammation, reflecting lymphoid cell turnover/reconstitution during chronic inflammation. These findings provide insight on intermediate stages of NK-cell development, a view of emergency recruitment of cell precursors, and upgrade our understanding and monitoring of chronic inflammatory conditions.

Suggested Citation

  • Federica Bozzano & Francesco Marras & Maria Libera Ascierto & Claudia Cantoni & Giovanni Cenderello & Chiara Dentone & Antonio Di Biagio & Giancarlo Orofino & Eugenio Mantia & Silvia Boni & Pasqualina, 2015. "‘Emergency exit’ of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation," Nature Communications, Nature, vol. 6(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9109
    DOI: 10.1038/ncomms9109
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms9109
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms9109?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9109. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.