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Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Author

Listed:
  • Yuan Lin

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Xuejiang Guo

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Bijun Zhao

    (Xijing hospital, The Fourth Military Medical University)

  • Juanjuan Liu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Min Da

    (Nanjing Children's Hospital, Nanjing Medical University)

  • Yang Wen

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Yuanli Hu

    (Nanjing Children's Hospital, Nanjing Medical University)

  • Bixian Ni

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Kai Zhang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Shiwei Yang

    (Nanjing Children's Hospital, Nanjing Medical University)

  • Jing Xu

    (The First Affiliated Hospital of Nanjing Medical University)

  • Juncheng Dai

    (School of Public Health, Nanjing Medical University)

  • Xiaowei Wang

    (The First Affiliated Hospital of Nanjing Medical University)

  • Yankai Xia

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Hongxia Ma

    (School of Public Health, Nanjing Medical University)

  • Guangfu Jin

    (School of Public Health, Nanjing Medical University)

  • Shiqiang Yu

    (Xijing hospital, The Fourth Military Medical University)

  • Jiayin Liu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University)

  • Bernard D. Keavney

    (Institute of Genetic Medicine, Newcastle University
    Institute of Cardiovascular Sciences, The University of Manchester)

  • Judith A. Goodship

    (Institute of Genetic Medicine, Newcastle University)

  • Heather J. Cordell

    (Institute of Genetic Medicine, Newcastle University)

  • Xinru Wang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Hongbing Shen

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Jiahao Sha

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Zuomin Zhou

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Yijiang Chen

    (The First Affiliated Hospital of Nanjing Medical University)

  • Xuming Mo

    (Nanjing Children's Hospital, Nanjing Medical University)

  • Lingfei Luo

    (Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University)

  • Zhibin Hu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

Abstract

Our previous genome-wide association study (GWAS) identified two susceptibility loci for congenital heart disease (CHD) in Han Chinese. Here we identify additional loci by testing promising associations in an extended 3-stage validation consisting of 6,053 CHD cases and 7,410 controls. We find GW significant (P

Suggested Citation

  • Yuan Lin & Xuejiang Guo & Bijun Zhao & Juanjuan Liu & Min Da & Yang Wen & Yuanli Hu & Bixian Ni & Kai Zhang & Shiwei Yang & Jing Xu & Juncheng Dai & Xiaowei Wang & Yankai Xia & Hongxia Ma & Guangfu Ji, 2015. "Association analysis identifies new risk loci for congenital heart disease in Chinese populations," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9082
    DOI: 10.1038/ncomms9082
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