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Refining the pathway of carbide insertion into the nitrogenase M-cluster

Author

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  • Jared A. Wiig

    (University of California)

  • Yilin Hu

    (University of California)

  • Markus W. Ribbe

    (University of California
    University of California)

Abstract

Carbide insertion plays a pivotal role in the biosynthesis of M-cluster, the cofactor of nitrogenase. Previously, we proposed a carbide insertion pathway involving methyltransfer from SAM to a FeS precursor and hydrogen abstraction from this methyl group that initiates the radical-based precursor maturation. Here we demonstrate that the methyl group is transferred to a precursor-associated sulfur before hydrogen abstraction, thereby refining the initial steps of the carbide insertion pathway.

Suggested Citation

  • Jared A. Wiig & Yilin Hu & Markus W. Ribbe, 2015. "Refining the pathway of carbide insertion into the nitrogenase M-cluster," Nature Communications, Nature, vol. 6(1), pages 1-6, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9034
    DOI: 10.1038/ncomms9034
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