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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

Author

Listed:
  • Gil Kanfer

    (Institute of Biochemistry, ETH Zürich)

  • Thibault Courthéoux

    (Institute of Biochemistry, ETH Zürich)

  • Martin Peterka

    (Institute of Biochemistry, ETH Zürich)

  • Sonja Meier

    (Institute of Biochemistry, ETH Zürich)

  • Martin Soste

    (Institute of Biochemistry, ETH Zürich)

  • Andre Melnik

    (Institute of Biochemistry, ETH Zürich)

  • Katarina Reis

    (Tumor and Cell Biology, Karolinska Institutet)

  • Pontus Aspenström

    (Tumor and Cell Biology, Karolinska Institutet)

  • Matthias Peter

    (Institute of Biochemistry, ETH Zürich)

  • Paola Picotti

    (Institute of Biochemistry, ETH Zürich)

  • Benoît Kornmann

    (Institute of Biochemistry, ETH Zürich)

Abstract

Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

Suggested Citation

  • Gil Kanfer & Thibault Courthéoux & Martin Peterka & Sonja Meier & Martin Soste & Andre Melnik & Katarina Reis & Pontus Aspenström & Matthias Peter & Paola Picotti & Benoît Kornmann, 2015. "Mitotic redistribution of the mitochondrial network by Miro and Cenp-F," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9015
    DOI: 10.1038/ncomms9015
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    Cited by:

    1. Keisuke Obara & Taku Yoshikawa & Ryu Yamaguchi & Keiko Kuwata & Kunio Nakatsukasa & Kohei Nishimura & Takumi Kamura, 2022. "Proteolysis of adaptor protein Mmr1 during budding is necessary for mitochondrial homeostasis in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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