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Batf is important for IL-4 expression in T follicular helper cells

Author

Listed:
  • Anupama Sahoo

    (MD Anderson Cancer Center)

  • Andrei Alekseev

    (MD Anderson Cancer Center)

  • Kentaro Tanaka

    (MD Anderson Cancer Center
    CNMC, Center for Cancer and Immunology Research, Children’s National Medical Center)

  • Lidiya Obertas

    (MD Anderson Cancer Center)

  • Beatrisa Lerman

    (MD Anderson Cancer Center)

  • Cara Haymaker

    (MD Anderson Cancer Center)

  • Karen Clise-Dwyer

    (MD Anderson Cancer Center)

  • John S. McMurray

    (MD Anderson Cancer Center)

  • Roza Nurieva

    (MD Anderson Cancer Center)

Abstract

Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF-like, Batf is important for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 and Stat6 trigger IL-4 production in Tfh cells by directly binding to and activation of the CNS2 region in the IL-4 locus. In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 expression in Tfh cells. Batf deficiency impairs the generation of IL-4-producing Tfh cells that results in protection against allergic asthma. Our results thus indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing Tfh cells.

Suggested Citation

  • Anupama Sahoo & Andrei Alekseev & Kentaro Tanaka & Lidiya Obertas & Beatrisa Lerman & Cara Haymaker & Karen Clise-Dwyer & John S. McMurray & Roza Nurieva, 2015. "Batf is important for IL-4 expression in T follicular helper cells," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8997
    DOI: 10.1038/ncomms8997
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