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MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent

Author

Listed:
  • Zhuxian Zhou

    (Case Western Reserve University
    Center for Bionanoengineering and State Key Laboratory of Chemical Engineering, Zhejiang University)

  • Mohammed Qutaish

    (Case Western Reserve University)

  • Zheng Han

    (Case Western Reserve University)

  • Rebecca M. Schur

    (Case Western Reserve University)

  • Yiqiao Liu

    (Case Western Reserve University)

  • David L. Wilson

    (Case Western Reserve University
    Case Western Reserve University)

  • Zheng-Rong Lu

    (Case Western Reserve University)

Abstract

Metastasis is the primary cause of death in breast cancer patients. Early detection of high-risk breast cancer, including micrometastasis, is critical in tailoring appropriate and effective interventional therapies. Increased fibronectin expression, a hallmark of epithelial-to-mesenchymal transition, is associated with high-risk breast cancer and metastasis. We have previously developed a penta-peptide CREKA (Cys-Arg-Glu-Lys-Ala)-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agent, CREKA-Tris(Gd-DOTA)3 (Gd-DOTA (4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecyl gadolinium), which binds to fibrin–fibronectin complexes that are abundant in the tumour microenvironment of fast-growing breast cancer. Here we assess the capability of CREKA-Tris(Gd-DOTA)3 to detect micrometastasis with MRI in co-registration with high-resolution fluorescence cryo-imaging in female mice bearing metastatic 4T1 breast tumours. We find that CREKA-Tris(Gd-DOTA)3 provides robust contrast enhancement in the metastatic tumours and enables the detection of micrometastases of size

Suggested Citation

  • Zhuxian Zhou & Mohammed Qutaish & Zheng Han & Rebecca M. Schur & Yiqiao Liu & David L. Wilson & Zheng-Rong Lu, 2015. "MRI detection of breast cancer micrometastases with a fibronectin-targeting contrast agent," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8984
    DOI: 10.1038/ncomms8984
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