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Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella

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  • Adrien Sicard

    (Institut für Biochemie und Biologie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, Haus 26, 14476 Potsdam-Golm, Germany)

  • Christian Kappel

    (Institut für Biochemie und Biologie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, Haus 26, 14476 Potsdam-Golm, Germany)

  • Emily B. Josephs

    (University of Toronto)

  • Young Wha Lee

    (University of Toronto)

  • Cindy Marona

    (Institut für Biochemie und Biologie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, Haus 26, 14476 Potsdam-Golm, Germany)

  • John R. Stinchcombe

    (University of Toronto)

  • Stephen I. Wright

    (University of Toronto)

  • Michael Lenhard

    (Institut für Biochemie und Biologie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, Haus 26, 14476 Potsdam-Golm, Germany)

Abstract

In the Bateson–Dobzhansky–Muller model of genetic incompatibilities post-zygotic gene-flow barriers arise by fixation of novel alleles at interacting loci in separated populations. Many such incompatibilities are polymorphic in plants, implying an important role for genetic drift or balancing selection in their origin and evolution. Here we show that NPR1 and RPP5 loci cause a genetic incompatibility between the incipient species Capsella grandiflora and C. rubella, and the more distantly related C. rubella and C. orientalis. The incompatible RPP5 allele results from a mutation in C. rubella, while the incompatible NPR1 allele is frequent in the ancestral C. grandiflora. Compatible and incompatible NPR1 haplotypes are maintained by balancing selection in C. grandiflora, and were divergently sorted into the derived C. rubella and C. orientalis. Thus, by maintaining differentiated alleles at high frequencies, balancing selection on ancestral polymorphisms can facilitate establishing gene-flow barriers between derived populations through lineage sorting of the alternative alleles.

Suggested Citation

  • Adrien Sicard & Christian Kappel & Emily B. Josephs & Young Wha Lee & Cindy Marona & John R. Stinchcombe & Stephen I. Wright & Michael Lenhard, 2015. "Divergent sorting of a balanced ancestral polymorphism underlies the establishment of gene-flow barriers in Capsella," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8960
    DOI: 10.1038/ncomms8960
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