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Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study

Author

Listed:
  • G. Paul Amminger

    (Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne)

  • Miriam R. Schäfer

    (Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne)

  • Monika Schlögelhofer

    (Medical University of Vienna)

  • Claudia M. Klier

    (Medical University of Vienna)

  • Patrick D. McGorry

    (Orygen—The National Centre of Excellence in Youth Mental Health, The University of Melbourne)

Abstract

Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.

Suggested Citation

  • G. Paul Amminger & Miriam R. Schäfer & Monika Schlögelhofer & Claudia M. Klier & Patrick D. McGorry, 2015. "Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8934
    DOI: 10.1038/ncomms8934
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