IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8889.html
   My bibliography  Save this article

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

Author

Listed:
  • Sylvain Meunier

    (Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF))

  • Maria Shvedunova

    (Max Planck Institute of Immunobiology and Epigenetics
    Faculty of Biology, University of Freiburg)

  • Nhuong Van Nguyen

    (Max Planck Institute of Immunobiology and Epigenetics
    Faculty of Biology, University of Freiburg)

  • Leonor Avila

    (Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF))

  • Isabelle Vernos

    (Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF)
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Asifa Akhtar

    (Max Planck Institute of Immunobiology and Epigenetics)

Abstract

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

Suggested Citation

  • Sylvain Meunier & Maria Shvedunova & Nhuong Van Nguyen & Leonor Avila & Isabelle Vernos & Asifa Akhtar, 2015. "An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8889
    DOI: 10.1038/ncomms8889
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms8889
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms8889?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ting Li & Dingyi Lu & Chengcheng Yao & Tingting Li & Hua Dong & Zhan Li & Guang Xu & Jiayi Chen & Hao Zhang & Xiaoyu Yi & Haizhen Zhu & Guangqin Liu & Kaiqing Wen & Haixin Zhao & Jun Gao & Yakun Zhang, 2022. "Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8889. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.