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Single-neuron activity and eye movements during human REM sleep and awake vision

Author

Listed:
  • Thomas Andrillon

    (Laboratoire de Sciences Cognitives et Psycholinguistique (UMR8554), EHESS/CNRS/ENS-DEC
    Ecole Doctorale Cerveau Cognition Comportement, ENS/EHESS/ParisVI/ParisV
    University of Wisconsin-Madison)

  • Yuval Nir

    (Sackler School of Medicine, and Sagol School of Neuroscience, Tel Aviv University)

  • Chiara Cirelli

    (University of Wisconsin-Madison)

  • Giulio Tononi

    (University of Wisconsin-Madison)

  • Itzhak Fried

    (David Geffen School of Medicine and Semel Institute For Neuroscience and Human Behavior, UCLA
    Functional Neurosurgery Unit, Tel Aviv Medical Center and Sackler School of Medicine, Tel Aviv University)

Abstract

Are rapid eye movements (REMs) in sleep associated with visual-like activity, as during wakefulness? Here we examine single-unit activities (n=2,057) and intracranial electroencephalography across the human medial temporal lobe (MTL) and neocortex during sleep and wakefulness, and during visual stimulation with fixation. During sleep and wakefulness, REM onsets are associated with distinct intracranial potentials, reminiscent of ponto-geniculate-occipital waves. Individual neurons, especially in the MTL, exhibit reduced firing rates before REMs as well as transient increases in firing rate immediately after, similar to activity patterns observed upon image presentation during fixation without eye movements. Moreover, the selectivity of individual units is correlated with their response latency, such that units activated after a small number of images or REMs exhibit delayed increases in firing rates. Finally, the phase of theta oscillations is similarly reset following REMs in sleep and wakefulness, and after controlled visual stimulation. Our results suggest that REMs during sleep rearrange discrete epochs of visual-like processing as during wakefulness.

Suggested Citation

  • Thomas Andrillon & Yuval Nir & Chiara Cirelli & Giulio Tononi & Itzhak Fried, 2015. "Single-neuron activity and eye movements during human REM sleep and awake vision," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8884
    DOI: 10.1038/ncomms8884
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    Cited by:

    1. Diego B. Piza & Benjamin W. Corrigan & Roberto A. Gulli & Sonia Carmo & A. Claudio Cuello & Lyle Muller & Julio Martinez-Trujillo, 2024. "Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Sun, Guoping & Yang, Feifei & Ren, Guodong & Wang, Chunni, 2023. "Energy encoding in a biophysical neuron and adaptive energy balance under field coupling," Chaos, Solitons & Fractals, Elsevier, vol. 169(C).

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