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MicroRNA-431 accelerates muscle regeneration and ameliorates muscular dystrophy by targeting Pax7 in mice

Author

Listed:
  • Rimao Wu

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Hu Li

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Lili Zhai

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Xiaoting Zou

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Jiao Meng

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Ran Zhong

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Changyin Li

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Haixia Wang

    (Gladstone Institute of Cardiovascular Disease, Roddenberry Center for Stem Cell Biology and Medicine)

  • Yong Zhang

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

  • Dahai Zhu

    (The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College)

Abstract

Skeletal muscle stem cells, called satellite cells, are a quiescent heterogeneous population. Their heterogeneity is influenced by Pax7, a well-defined transcriptional regulator of satellite cell functions that defines two subpopulations: Pax7Hi and Pax7Lo. However, the mechanisms by which these subpopulations are established and maintained during myogenesis are not completely understood. Here we show that miR-431, which is predominantly expressed in the skeletal muscle, mediates satellite cell heterogeneity by fine-tuning Pax7 levels during muscle development and regeneration. In miR-431 transgenic mice, the Pax7Lo subpopulation is enriched, enhances myogenic differentiation and accelerates muscle regeneration. Notably, miR-431 attenuates the muscular dystrophic phenotype in mdx mice and may be a potential therapeutic target in muscular diseases. miR-431 transgenic mice are a unique genetic model for investigating the cellular features and biological functions of Pax7Lo satellite cells during muscle development and regeneration.

Suggested Citation

  • Rimao Wu & Hu Li & Lili Zhai & Xiaoting Zou & Jiao Meng & Ran Zhong & Changyin Li & Haixia Wang & Yong Zhang & Dahai Zhu, 2015. "MicroRNA-431 accelerates muscle regeneration and ameliorates muscular dystrophy by targeting Pax7 in mice," Nature Communications, Nature, vol. 6(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8713
    DOI: 10.1038/ncomms8713
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    Cited by:

    1. Xiaodi Hu & Mingwei Sun & Qian Chen & Yixia Zhao & Na Liang & Siyuan Wang & Pengbin Yin & Yuanping Yang & Sin Man Lam & Qianying Zhang & Alimujiang Tudiyusufu & Yingying Gu & Xin Wan & Meihong Chen & , 2023. "Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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