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A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking

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  • Yi-xiao Luo

    (Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
    National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Yan-xue Xue

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Jian-feng Liu

    (Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
    National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Hai-shui Shi

    (Basic Medical College, Hebei Medical University)

  • Min Jian

    (Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
    National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Ying Han

    (Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
    National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Wei-li Zhu

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Yan-ping Bao

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Ping Wu

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Zeng-bo Ding

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Hao-wei Shen

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Jie Shi

    (National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University)

  • Yavin Shaham

    (Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health)

  • Lin Lu

    (Institute of Mental Health/Peking University Sixth Hospital, Key Laboratory of Mental Health, Peking University
    National Institute on Drug Dependence, Beijing Key Laboratory of Drug Dependence Research, Peking University
    Peking-Tsinghua Center for Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University)

Abstract

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.

Suggested Citation

  • Yi-xiao Luo & Yan-xue Xue & Jian-feng Liu & Hai-shui Shi & Min Jian & Ying Han & Wei-li Zhu & Yan-ping Bao & Ping Wu & Zeng-bo Ding & Hao-wei Shen & Jie Shi & Yavin Shaham & Lin Lu, 2015. "A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking," Nature Communications, Nature, vol. 6(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8675
    DOI: 10.1038/ncomms8675
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