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Injectable cryogel-based whole-cell cancer vaccines

Author

Listed:
  • Sidi A. Bencherif

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University
    Sorbonne University, UTC CNRS UMR 7338, Biomechanics and Bioengineering (BMBI), University of Technology of Compiègne)

  • R. Warren Sands

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University
    University of Pittsburgh Medical Center Department of Medicine)

  • Omar A. Ali

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Weiwei A. Li

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Sarah A. Lewin

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Thomas M. Braschler

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University
    School of Engineering, LMIS4, Station 17, École polytechnique fédérale de Lausanne)

  • Ting-Yu Shih

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Catia S. Verbeke

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Deen Bhatta

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

  • Glenn Dranoff

    (Brigham and Women’s Hospital and Harvard Medical School)

  • David J. Mooney

    (School of Engineering and Applied Sciences, Harvard University
    Wyss Institute for Biologically Inspired Engineering at Harvard University)

Abstract

A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we encapsulate GM-CSF, serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like macroporous cryogels. These cryogels are injected subcutaneously into mice to localize transplanted tumour cells and deliver immunomodulatory factors in a controlled spatio-temporal manner. These vaccines elicit local infiltrates composed of conventional and plasmacytoid DCs, with the subsequent induction of potent, durable and specific anti-tumour T-cell responses in a melanoma model. These cryogels can be delivered in a minimally invasive manner, bypass the need for genetic modification of transplanted cancer cells and provide sustained release of immunomodulators. Altogether, these findings indicate the potential for cryogels to serve as a platform for cancer cell vaccinations.

Suggested Citation

  • Sidi A. Bencherif & R. Warren Sands & Omar A. Ali & Weiwei A. Li & Sarah A. Lewin & Thomas M. Braschler & Ting-Yu Shih & Catia S. Verbeke & Deen Bhatta & Glenn Dranoff & David J. Mooney, 2015. "Injectable cryogel-based whole-cell cancer vaccines," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8556
    DOI: 10.1038/ncomms8556
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    Cited by:

    1. Ying Zhang & Raghava N. Sriramaneni & Paul A. Clark & Justin C. Jagodinsky & Mingzhou Ye & Wonjong Jin & Yuyuan Wang & Amber Bates & Caroline P. Kerr & Trang Le & Raad Allawi & Xiuxiu Wang & Ruosen Xi, 2022. "Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Kwasi Adu-Berchie & Joshua M. Brockman & Yutong Liu & Tania W. To & David K. Y. Zhang & Alexander J. Najibi & Yoav Binenbaum & Alexander Stafford & Nikolaos Dimitrakakis & Miguel C. Sobral & Maxence O, 2023. "Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Jiaqi Meng & Yanlin Lv & Weier Bao & Zihui Meng & Shuang Wang & Yuanbin Wu & Shuping Li & Zhouguang Jiao & Zhiyuan Tian & Guanghui Ma & Wei Wei, 2023. "Generation of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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