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The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium

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  • Balaji Santhanam

    (Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine
    Baylor College of Medicine)

  • Huaqing Cai

    (School of Medicine, Johns Hopkins University)

  • Peter N. Devreotes

    (School of Medicine, Johns Hopkins University)

  • Gad Shaulsky

    (Baylor College of Medicine)

  • Mariko Katoh-Kurasawa

    (Baylor College of Medicine)

Abstract

In many systems, including the social amoeba Dictyostelium discoideum, development is often marked by dynamic morphological and transcriptional changes orchestrated by key transcription factors. However, efforts to examine sequential genome-wide changes of gene regulation in developmental processes have been fairly limited. Here we report the developmental regulatory dynamics of GtaC, a GATA-type zinc-finger transcription factor, through the analyses of serial ChIP- and RNA-sequencing data. GtaC is essential for developmental progression, decoding extracellular cAMP pulses during early development and may play a role in mediating cell-type differentiation at later stages. We find that GtaC exhibits temporally distinctive DNA-binding patterns concordant with each developmental stage. We identify direct GtaC targets and observe cotemporaneous GtaC-binding and developmental expression regulation. Our results suggest that GtaC regulates multiple physiological processes as Dictyostelium transitions from a group of unicellular amoebae to an integrated multicellular organism.

Suggested Citation

  • Balaji Santhanam & Huaqing Cai & Peter N. Devreotes & Gad Shaulsky & Mariko Katoh-Kurasawa, 2015. "The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8551
    DOI: 10.1038/ncomms8551
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    Cited by:

    1. Sanea Sheikh & Cheng-Jie Fu & Matthew W. Brown & Sandra L. Baldauf, 2024. "The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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