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A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime

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Listed:
  • Pablo Hernández-Varas

    (Karolinska Institutet)

  • Ulrich Berge

    (Karolinska Institutet)

  • John G. Lock

    (Karolinska Institutet)

  • Staffan Strömblad

    (Karolinska Institutet)

Abstract

Cell-matrix adhesions are central mediators of mechanotransduction, yet the interplay between force and adhesion regulation remains unclear. Here we use live cell imaging to map time-dependent cross-correlations between vinculin-mediated tension and adhesion complex area, revealing a plastic, context-dependent relationship. Interestingly, while an expected positive cross-correlation dominated in mid-sized adhesions, small and large adhesions display negative cross-correlation. Furthermore, although large changes in adhesion complex area follow vinculin-mediated tension alterations, small increases in area precede vinculin-mediated tension dynamics. Modelling based on this mapping of the vinculin-mediated tension-adhesion complex area relationship confirms its biological validity, and indicates that this relationship explains adhesion size and lifetime limits, keeping adhesions focal and transient. We also identify a subpopulation of steady-state adhesions whose size and vinculin-mediated tension become stabilized, and whose disassembly may be selectively microtubule-mediated. In conclusion, we define a plastic relationship between vinculin-mediated tension and adhesion complex area that controls fundamental cell-matrix adhesion properties.

Suggested Citation

  • Pablo Hernández-Varas & Ulrich Berge & John G. Lock & Staffan Strömblad, 2015. "A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8524
    DOI: 10.1038/ncomms8524
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    Cited by:

    1. Jacob M Kowalewski & Hamdah Shafqat-Abbasi & Mehrdad Jafari-Mamaghani & Bereket Endrias Ganebo & Xiaowei Gong & Staffan Strömblad & John G Lock, 2015. "Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-23, August.

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