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Exosomes released by keratinocytes modulate melanocyte pigmentation

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  • Alessandra Lo Cicero

    (Institut Curie, PSL Research University
    Structure and Membrane Compartments, Centre National de la Recherche Scientifique
    Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA))

  • Cédric Delevoye

    (Institut Curie, PSL Research University
    Structure and Membrane Compartments, Centre National de la Recherche Scientifique)

  • Floriane Gilles-Marsens

    (Institut Curie, PSL Research University
    Structure and Membrane Compartments, Centre National de la Recherche Scientifique)

  • Damarys Loew

    (Institut Curie, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique)

  • Florent Dingli

    (Institut Curie, Centre de Recherche, Laboratoire de Spectrométrie de Masse Protéomique)

  • Christelle Guéré

    (Laboratoires Clarins—31 chaussée Jules César)

  • Nathalie André

    (Laboratoires Clarins—31 chaussée Jules César)

  • Katell Vié

    (Laboratoires Clarins—31 chaussée Jules César)

  • Guillaume van Niel

    (Institut Curie, PSL Research University
    Structure and Membrane Compartments, Centre National de la Recherche Scientifique
    Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA))

  • Graça Raposo

    (Institut Curie, PSL Research University
    Structure and Membrane Compartments, Centre National de la Recherche Scientifique
    Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA))

Abstract

Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.

Suggested Citation

  • Alessandra Lo Cicero & Cédric Delevoye & Floriane Gilles-Marsens & Damarys Loew & Florent Dingli & Christelle Guéré & Nathalie André & Katell Vié & Guillaume van Niel & Graça Raposo, 2015. "Exosomes released by keratinocytes modulate melanocyte pigmentation," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8506
    DOI: 10.1038/ncomms8506
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