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A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture

Author

Listed:
  • Jacek Krol

    (Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research)

  • Ilona Krol

    (Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research
    Present address: Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland)

  • Claudia Patricia Patino Alvarez

    (Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research)

  • Michele Fiscella

    (Bio Engineering Laboratory, ETH Zurich)

  • Andreas Hierlemann

    (Bio Engineering Laboratory, ETH Zurich)

  • Botond Roska

    (Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research
    Faculty of Medicine, University of Basel)

  • Witold Filipowicz

    (Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research
    Biozentrum, University of Basel)

Abstract

Brain regions, such as the cortex and retina, are composed of layers of uniform thickness. The molecular mechanism that controls this uniformity is not well understood. Here we show that during mouse postnatal development the timed expression of Rncr4, a retina-specific long noncoding RNA, regulates the similarly timed processing of pri-miR-183/96/182, which is repressed at an earlier developmental stage by RNA helicase Ddx3x. Shifting the timing of mature miR-183/96/182 accumulation or interfering with Ddx3x expression leads to the disorganization of retinal architecture, with the photoreceptor layer being most affected. We identify Crb1, a component of the adhesion belt between glial and photoreceptor cells, as a link between Rncr4-regulated miRNA metabolism and uniform retina layering. Our results suggest that the precise timing of glia–neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers.

Suggested Citation

  • Jacek Krol & Ilona Krol & Claudia Patricia Patino Alvarez & Michele Fiscella & Andreas Hierlemann & Botond Roska & Witold Filipowicz, 2015. "A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8305
    DOI: 10.1038/ncomms8305
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    Cited by:

    1. Fang Ye & Guodong Zhang & Weigao E. & Haide Chen & Chengxuan Yu & Lei Yang & Yuting Fu & Jiaqi Li & Sulei Fu & Zhongyi Sun & Lijiang Fei & Qile Guo & Jingjing Wang & Yanyu Xiao & Xinru Wang & Peijing , 2022. "Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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