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Multiple independent autonomous hydraulic oscillators driven by a common gravity head

Author

Listed:
  • Sung-Jin Kim

    (Konkuk University
    University of Michigan)

  • Ryuji Yokokawa

    (University of Michigan
    Kyoto University)

  • Sasha Cai Lesher-Perez

    (University of Michigan)

  • Shuichi Takayama

    (University of Michigan
    University of Michigan
    Biointerfaces Institute, 2800 Plymouth Road, NCRC Building 10 A183, Ann Arbor, Michigan 48109, USA
    University of Michigan Center for Integrative Research in Critical Care (MCIRCC), Building 10-103A, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, Michigan 48109, USA)

Abstract

Self-switching microfluidic circuits that are able to perform biochemical experiments in a parallel and autonomous manner, similar to instruction-embedded electronics, are rarely implemented. Here, we present design principles and demonstrations for gravity-driven, integrated, microfluidic pulsatile flow circuits. With a common gravity head as the only driving force, these fluidic oscillator arrays realize a wide range of periods (0.4 s–2 h) and flow rates (0.10–63 μl min−1) with completely independent timing between the multiple oscillator sub-circuits connected in parallel. As a model application, we perform systematic, parallel analysis of endothelial cell elongation response to different fluidic shearing patterns generated by the autonomous microfluidic pulsed flow generation system.

Suggested Citation

  • Sung-Jin Kim & Ryuji Yokokawa & Sasha Cai Lesher-Perez & Shuichi Takayama, 2015. "Multiple independent autonomous hydraulic oscillators driven by a common gravity head," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8301
    DOI: 10.1038/ncomms8301
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