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Physical principles of membrane remodelling during cell mechanoadaptation

Author

Listed:
  • Anita Joanna Kosmalska

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona)

  • Laura Casares

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona)

  • Alberto Elosegui-Artola

    (Institute for Bioengineering of Catalonia (IBEC))

  • Joseph Jose Thottacherry

    (National Centre for Biological Sciences (TIFR))

  • Roberto Moreno-Vicente

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC))

  • Víctor González-Tarragó

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona)

  • Miguel Ángel del Pozo

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC))

  • Satyajit Mayor

    (National Centre for Biological Sciences (TIFR))

  • Marino Arroyo

    (LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech)

  • Daniel Navajas

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona
    Ciber Enfermedades Respiratorias)

  • Xavier Trepat

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

  • Nils C. Gauthier

    (Mechanobiology Institute, National University of Singapore)

  • Pere Roca-Cusachs

    (Institute for Bioengineering of Catalonia (IBEC)
    University of Barcelona)

Abstract

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope—the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell–substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes.

Suggested Citation

  • Anita Joanna Kosmalska & Laura Casares & Alberto Elosegui-Artola & Joseph Jose Thottacherry & Roberto Moreno-Vicente & Víctor González-Tarragó & Miguel Ángel del Pozo & Satyajit Mayor & Marino Arroyo , 2015. "Physical principles of membrane remodelling during cell mechanoadaptation," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8292
    DOI: 10.1038/ncomms8292
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    Cited by:

    1. Anabel-Lise Le Roux & Caterina Tozzi & Nikhil Walani & Xarxa Quiroga & Dobryna Zalvidea & Xavier Trepat & Margarita Staykova & Marino Arroyo & Pere Roca-Cusachs, 2021. "Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Céline Dinet & Alejandro Torres-Sánchez & Roberta Lanfranco & Lorenzo Michele & Marino Arroyo & Margarita Staykova, 2023. "Patterning and dynamics of membrane adhesion under hydraulic stress," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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