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Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle

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  • Kian-Yong Lee

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    Present address: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California 92093, USA)

  • Behrooz Esmaeili

    (Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK)

  • Ben Zealley

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Present address: SENS Research Foundation, Mountain View, California 94041, USA)

  • Masanori Mishima

    (Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK)

Abstract

During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dynein-generated cortical pulling forces, which determine spindle positioning and drive chromosome segregation through spindle elongation. The central spindle should be flexible enough for efficient chromosome segregation while maintaining its structural integrity for reliable cytokinesis. How the cell balances these potentially conflicting requirements is poorly understood. Here, we demonstrate that the central spindle in C. elegans embryos has a resilient mechanism for recovery from perturbations by excess tension derived from cortical pulling forces. This mechanism involves the direct interaction of two different types of conserved microtubule bundlers that are crucial for central spindle formation, PRC1 and centralspindlin.

Suggested Citation

  • Kian-Yong Lee & Behrooz Esmaeili & Ben Zealley & Masanori Mishima, 2015. "Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8290
    DOI: 10.1038/ncomms8290
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    Cited by:

    1. Wei Ming Lim & Wei-Xiang Chew & Arianna Esposito Verza & Marion Pesenti & Andrea Musacchio & Thomas Surrey, 2024. "Regulation of minimal spindle midzone organization by mitotic kinases," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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