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Auditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus

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  • Xiaorui R. Xiong

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Neuroscience Graduate Program, University of Southern California)

  • Feixue Liang

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    School of Basic Medical Sciences, Southern Medical University)

  • Brian Zingg

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Neuroscience Graduate Program, University of Southern California)

  • Xu-ying Ji

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    School of Basic Medical Sciences, Southern Medical University)

  • Leena A. Ibrahim

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Neuroscience Graduate Program, University of Southern California)

  • Huizhong W. Tao

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

  • Li I. Zhang

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

Abstract

Defense against environmental threats is essential for animal survival. However, the neural circuits responsible for transforming unconditioned sensory stimuli and generating defensive behaviours remain largely unclear. Here, we show that corticofugal neurons in the auditory cortex (ACx) targeting the inferior colliculus (IC) mediate an innate, sound-induced flight behaviour. Optogenetic activation of these neurons, or their projection terminals in the IC, is sufficient for initiating flight responses, while the inhibition of these projections reduces sound-induced flight responses. Corticocollicular axons monosynaptically innervate neurons in the cortex of the IC (ICx), and optogenetic activation of the projections from the ICx to the dorsal periaqueductal gray is sufficient for provoking flight behaviours. Our results suggest that ACx can both amplify innate acoustic-motor responses and directly drive flight behaviours in the absence of sound input through corticocollicular projections to ICx. Such corticofugal control may be a general feature of innate defense circuits across sensory modalities.

Suggested Citation

  • Xiaorui R. Xiong & Feixue Liang & Brian Zingg & Xu-ying Ji & Leena A. Ibrahim & Huizhong W. Tao & Li I. Zhang, 2015. "Auditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus," Nature Communications, Nature, vol. 6(1), pages 1-12, November.
  • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8224
    DOI: 10.1038/ncomms8224
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    Cited by:

    1. Jiashu Liu & Yingtian He & Andreanne Lavoie & Guy Bouvier & Bao-hua Liu, 2023. "A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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