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Comprehensive survey of condition-specific reproductive isolation reveals genetic incompatibility in yeast

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Listed:
  • Jing Hou

    (Genomics and Microbiology, University of Strasbourg/CNRS)

  • Anne Friedrich

    (Genomics and Microbiology, University of Strasbourg/CNRS)

  • Jean-Sebastien Gounot

    (Genomics and Microbiology, University of Strasbourg/CNRS)

  • Joseph Schacherer

    (Genomics and Microbiology, University of Strasbourg/CNRS)

Abstract

Genetic variation within a species could cause negative epistasis leading to reduced hybrid fitness and post-zygotic reproductive isolation. Recent studies in yeasts revealed chromosomal rearrangements as a major mechanism dampening intraspecific hybrid fertility on rich media. Here, by analysing a large number of Saccharomyces cerevisiae crosses on different culture conditions, we show environment-specific genetic incompatibility segregates readily within yeast and contributes to reproductive isolation. Over 24% (117 out of 481) of cases tested show potential epistasis, among which 6.7% (32 out of 481) are severe, with at least 20% of progeny loss on tested conditions. Based on the segregation patterns, we further characterize a two-locus Dobzhansky–Müller incompatibility case leading to offspring respiratory deficiency caused by nonsense mutation in a nuclear-encoding mitochondrial gene and tRNA suppressor. We provide evidence that this precise configuration could be adaptive in fluctuating environments, highlighting the role of ecological selection in the onset of genetic incompatibility and reproductive isolation in yeast.

Suggested Citation

  • Jing Hou & Anne Friedrich & Jean-Sebastien Gounot & Joseph Schacherer, 2015. "Comprehensive survey of condition-specific reproductive isolation reveals genetic incompatibility in yeast," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8214
    DOI: 10.1038/ncomms8214
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    Cited by:

    1. David Peris & Emily J. Ubbelohde & Meihua Christina Kuang & Jacek Kominek & Quinn K. Langdon & Marie Adams & Justin A. Koshalek & Amanda Beth Hulfachor & Dana A. Opulente & David J. Hall & Katie Hyma , 2023. "Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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