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Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

Author

Listed:
  • Henry R. Hampton

    (The Garvan Institute of Medical Research
    St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia, 390 Victoria street)

  • Jacqueline Bailey

    (The Garvan Institute of Medical Research)

  • Michio Tomura

    (Laboratory of Immunology Faculty of Pharmacy, Osaka-Ohtani University 3-11-1 Nishikiorikita,Tondabayashi-city, Osaka prefecture)

  • Robert Brink

    (The Garvan Institute of Medical Research
    St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia, 390 Victoria street)

  • Tatyana Chtanova

    (The Garvan Institute of Medical Research
    St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia, 390 Victoria street)

Abstract

Neutrophil recruitment to the site of injury is an essential first step of an anti-bacterial response. However, little is known about the basis for and relevance of neutrophil migration from inflamed tissue into lymphoid organs. We established a photoconversion-based system to monitor the fate of neutrophils recruited to inflamed skin. While neutrophils are efficiently recruited to sites of both microbial and sterile lesions, subsequent re-localization to draining lymph nodes happens only when bacteria are present in the primary lesion. Skin egress of neutrophils occurs via lymphatic vessels and is dependent on CD11b and CXCR4 but not CCR7. Neutrophils are the predominant immune cell to migrate from inflamed skin into lymph nodes where they augment lymphocyte proliferation. Furthermore, inhibition of neutrophil migration from skin reduces T-cell proliferation in draining lymph nodes. Thus neutrophils mediate rapid cellular communication between the initial injury site and secondary lymphoid organs and modulate immune responsiveness.

Suggested Citation

  • Henry R. Hampton & Jacqueline Bailey & Michio Tomura & Robert Brink & Tatyana Chtanova, 2015. "Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8139
    DOI: 10.1038/ncomms8139
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    Cited by:

    1. Joern Pezoldt & Carolin Wiechers & Mangge Zou & Maria Litovchenko & Marjan Biocanin & Michael Beckstette & Katarzyna Sitnik & Martina Palatella & Guido Mierlo & Wanze Chen & Vincent Gardeux & Stefan F, 2022. "Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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