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A common assembly module in injectisome and flagellar type III secretion sorting platforms

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  • Ryan Q. Notti

    (Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Tri-Institutional Medical Scientist Training Program, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10021, USA)

  • Shibani Bhattacharya

    (New York Structural Biology Center, 89 Convent Avenue, New York, New York 10027, USA)

  • Mirjana Lilic

    (Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • C. Erec Stebbins

    (Laboratory of Structural Microbiology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

Abstract

Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design.

Suggested Citation

  • Ryan Q. Notti & Shibani Bhattacharya & Mirjana Lilic & C. Erec Stebbins, 2015. "A common assembly module in injectisome and flagellar type III secretion sorting platforms," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8125
    DOI: 10.1038/ncomms8125
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