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Muscle stem cells contribute to myofibres in sedentary adult mice

Author

Listed:
  • Alexandra C. Keefe

    (University of Utah)

  • Jennifer A. Lawson

    (University of Utah)

  • Steven D. Flygare

    (University of Utah)

  • Zachary D. Fox

    (University of Utah)

  • Mary P. Colasanto

    (University of Utah)

  • Sam J. Mathew

    (University of Utah
    Present address: Regional Centre for Biotechnology, Gurgaon 122016, India)

  • Mark Yandell

    (University of Utah
    USTAR Center for Genetic Discovery, University of Utah)

  • Gabrielle Kardon

    (University of Utah)

Abstract

Skeletal muscle is essential for mobility, stability and whole body metabolism, and muscle loss, for instance, during sarcopenia, has profound consequences. Satellite cells (muscle stem cells) have been hypothesized, but not yet demonstrated, to contribute to muscle homeostasis and a decline in their contribution to myofibre homeostasis to play a part in sarcopenia. To test their role in muscle maintenance, we genetically labelled and ablated satellite cells in adult sedentary mice. We demonstrate via genetic lineage experiments that, even in the absence of injury, satellite cells contribute to myofibres in all adult muscles, although the extent and timing differs. However, genetic ablation experiments showed that satellite cells are not globally required to maintain myofibre cross-sectional area of uninjured adult muscle.

Suggested Citation

  • Alexandra C. Keefe & Jennifer A. Lawson & Steven D. Flygare & Zachary D. Fox & Mary P. Colasanto & Sam J. Mathew & Mark Yandell & Gabrielle Kardon, 2015. "Muscle stem cells contribute to myofibres in sedentary adult mice," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8087
    DOI: 10.1038/ncomms8087
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    Cited by:

    1. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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