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The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome

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  • Yang Zhou

    (Biochemistry Center (BZH), Heidelberg University)

  • Jianguo Zhu

    (Biochemistry Center (BZH), Heidelberg University)

  • Géza Schermann

    (Biochemistry Center (BZH), Heidelberg University)

  • Corina Ohle

    (Biochemistry Center (BZH), Heidelberg University)

  • Katja Bendrin

    (Biochemistry Center (BZH), Heidelberg University)

  • Rie Sugioka-Sugiyama

    (Faculty of Life and Environmental Sciences, University of Tsukuba)

  • Tomoyasu Sugiyama

    (Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba)

  • Tamás Fischer

    (Biochemistry Center (BZH), Heidelberg University)

Abstract

Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. The MTREC complex specifically binds to CUTs, meiotic mRNAs and unspliced pre-mRNA transcripts and targets these RNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process. The MTREC complex physically interacts with the nuclear exosome and with various RNA-binding and RNA-processing complexes, coupling RNA processing to the RNA degradation machinery. Our study reveals the central role of the evolutionarily conserved MTREC complex in RNA quality control, and in the recognition and elimination of CUTs.

Suggested Citation

  • Yang Zhou & Jianguo Zhu & Géza Schermann & Corina Ohle & Katja Bendrin & Rie Sugioka-Sugiyama & Tomoyasu Sugiyama & Tamás Fischer, 2015. "The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome," Nature Communications, Nature, vol. 6(1), pages 1-11, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8050
    DOI: 10.1038/ncomms8050
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    Cited by:

    1. Komal Soni & Anusree Sivadas & Attila Horvath & Nikolay Dobrev & Rippei Hayashi & Leo Kiss & Bernd Simon & Klemens Wild & Irmgard Sinning & Tamás Fischer, 2023. "Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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