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Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

Author

Listed:
  • Changgui Li

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Zhiqiang Li

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University)

  • Shiguo Liu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Can Wang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Lin Han

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Lingling Cui

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Jingguo Zhou

    (North Sichuan Medical College)

  • Hejian Zou

    (The Affiliated Huashan Hospital of Fudan University)

  • Zhen Liu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Jianhua Chen

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University)

  • Xiaoyu Cheng

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Zhaowei Zhou

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Chengcheng Ding

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Meng Wang

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University)

  • Tong Chen

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Ying Cui

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Hongmei He

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Keke Zhang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Congcong Yin

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University
    Henry Ford Immunology Program, Henry Ford Health System)

  • Yunlong Wang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Shichao Xing

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Baojie Li

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)

  • Jue Ji

    (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University)

  • Zhaotong Jia

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Lidan Ma

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Jiapeng Niu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Ying Xin

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Tian Liu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Nan Chu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Qing Yu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Wei Ren

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Xuefeng Wang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Aiqing Zhang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Yuping Sun

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Haili Wang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Jie Lu

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Yuanyuan Li

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Yufeng Qing

    (North Sichuan Medical College)

  • Gang Chen

    (Fujian Provincial Hospital, Fujian Medical University)

  • Yangang Wang

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Li Zhou

    (Henry Ford Immunology Program, Henry Ford Health System
    Henry Ford Health System
    Henry Ford Health System)

  • Haitao Niu

    (The Affiliated Hospital of Medical College Qingdao University)

  • Jun Liang

    (The Affiliated Hospital of Qingdao University Medical College)

  • Qian Dong

    (The Affiliated Hospital of Qingdao University Medical College)

  • Xinde Li

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University)

  • Qing-Sheng Mi

    (Henry Ford Immunology Program, Henry Ford Health System
    Henry Ford Health System
    Henry Ford Health System)

  • Yongyong Shi

    (Shandong Gout Clinical Medical Center
    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University
    Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University
    Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University)

Abstract

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of monosodium urate crystals in and around the joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum urate concentrations. However, hyperuricemia alone is not sufficient for the development of gout arthritis. Here we conduct a multistage GWAS in Han Chinese using 4,275 male gout patients and 6,272 normal male controls (1,255 cases and 1,848 controls were genome-wide genotyped), with an additional 1,644 hyperuricemic controls. We discover three new risk loci, 17q23.2 (rs11653176, P=1.36 × 10−13, BCAS3), 9p24.2 (rs12236871, P=1.48 × 10−10, RFX3) and 11p15.5 (rs179785, P=1.28 × 10−8, KCNQ1), which contain inflammatory candidate genes. Our results suggest that these loci are most likely related to the progression from hyperuricemia to inflammatory gout, which will provide new insights into the pathogenesis of gout arthritis.

Suggested Citation

  • Changgui Li & Zhiqiang Li & Shiguo Liu & Can Wang & Lin Han & Lingling Cui & Jingguo Zhou & Hejian Zou & Zhen Liu & Jianhua Chen & Xiaoyu Cheng & Zhaowei Zhou & Chengcheng Ding & Meng Wang & Tong Chen, 2015. "Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese," Nature Communications, Nature, vol. 6(1), pages 1-6, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8041
    DOI: 10.1038/ncomms8041
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