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Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

Author

Listed:
  • Lam C. Tsoi

    (Center for Statistical Genetics, University of Michigan)

  • Sarah L. Spain

    (King’s College London
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Eva Ellinghaus

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Philip E. Stuart

    (University of Michigan)

  • Francesca Capon

    (King’s College London)

  • Jo Knight

    (Neuroscience Research, Centre for Addiction and Mental Health
    National Institute for Health Research (NIHR), Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust)

  • Trilokraj Tejasvi

    (University of Michigan)

  • Hyun M. Kang

    (Center for Statistical Genetics, University of Michigan)

  • Michael H. Allen

    (King’s College London)

  • Sylviane Lambert

    (University of Michigan)

  • Stefan W. Stoll

    (University of Michigan)

  • Stephan Weidinger

    (University Hospital, Schleswig-Holstein, Christian-Albrechts-University)

  • Johann E. Gudjonsson

    (University of Michigan)

  • Sulev Koks

    (Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu)

  • Külli Kingo

    (University of Tartu)

  • Tonu Esko

    (Estonian Genome Center, University of Tartu)

  • Sayantan Das

    (Center for Statistical Genetics, University of Michigan)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Michael Weichenthal

    (University Hospital, Schleswig-Holstein, Christian-Albrechts-University)

  • Charlotta Enerback

    (Linköping University)

  • Gerald G. Krueger

    (University of Utah)

  • John J. Voorhees

    (University of Michigan)

  • Vinod Chandran

    (University of Toronto, Toronto Western Hospital)

  • Cheryl F. Rosen

    (University of Toronto, Toronto Western Hospital)

  • Proton Rahman

    (Memorial University)

  • Dafna D. Gladman

    (University of Toronto, Toronto Western Hospital)

  • Andre Reis

    (Institute of Human Genetics, University of Erlangen-Nuremberg)

  • Rajan P. Nair

    (University of Michigan)

  • Andre Franke

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Jonathan N.W.N. Barker

    (King’s College London)

  • Goncalo R. Abecasis

    (Center for Statistical Genetics, University of Michigan)

  • Richard C. Trembath

    (Barts and the London School of Medicine and Dentistry, Queen Mary University of London)

  • James T. Elder

    (University of Michigan
    Ann Arbor Veterans Affairs Hospital)

Abstract

Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P

Suggested Citation

  • Lam C. Tsoi & Sarah L. Spain & Eva Ellinghaus & Philip E. Stuart & Francesca Capon & Jo Knight & Trilokraj Tejasvi & Hyun M. Kang & Michael H. Allen & Sylviane Lambert & Stefan W. Stoll & Stephan Weid, 2015. "Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci," Nature Communications, Nature, vol. 6(1), pages 1-8, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8001
    DOI: 10.1038/ncomms8001
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    Citations

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    Cited by:

    1. Matthew T. Patrick & Qinmengge Li & Rachael Wasikowski & Nehal Mehta & Johann E. Gudjonsson & James T. Elder & Xiang Zhou & Lam C. Tsoi, 2022. "Shared genetic risk factors and causal association between psoriasis and coronary artery disease," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Elmo C. Saarentaus & Juha Karjalainen & Joel T. Rämö & Tuomo Kiiskinen & Aki S. Havulinna & Juha Mehtonen & Heidi Hautakangas & Sanni Ruotsalainen & Max Tamlander & Nina Mars & Sanna Toppila-Salmi & M, 2023. "Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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