IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms7980.html
   My bibliography  Save this article

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Author

Listed:
  • Rachel J. Perry

    (Howard Hughes Medical Institute, Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Sangwon Lee

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Lie Ma

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Dongyan Zhang

    (Howard Hughes Medical Institute, Yale University School of Medicine)

  • Joseph Schlessinger

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Gerald I. Shulman

    (Howard Hughes Medical Institute, Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

Abstract

Fibroblast growth factor-1 (FGF1) and FGF19 have been shown to improve glucose metabolism in diabetic rodents, but how this occurs is unknown. Here to investigate the mechanism of action of these growth factors, we perform intracerebroventricular (ICV) injections of recombinant FGF1 or FGF19 in an awake rat model of type 1 diabetes (T1D) and measure rates of whole-body lipolysis, hepatic acetyl CoA content, pyruvate carboxylase activity and hepatic glucose production. We show that ICV injection of FGF19 or FGF1 leads to a ∼60% reduction in hepatic glucose production, hepatic acetyl CoA content and whole-body lipolysis, which results from decreases in plasma ACTH and corticosterone concentrations. These effects are abrogated by an intra-arterial infusion of corticosterone. Taken together these studies identify suppression of the HPA axis and ensuing reductions in hepatic acetyl CoA content as a common mechanism responsible for mediating the acute, insulin-independent, glucose-lowering effects of FGF1 and FGF19 in rodents with poorly controlled T1D.

Suggested Citation

  • Rachel J. Perry & Sangwon Lee & Lie Ma & Dongyan Zhang & Joseph Schlessinger & Gerald I. Shulman, 2015. "FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7980
    DOI: 10.1038/ncomms7980
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms7980
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms7980?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7980. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.