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Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry

Author

Listed:
  • Ilya Kuznetsov

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University)

  • Jorge Filevich

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University)

  • Feng Dong

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University)

  • Mark Woolston

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University)

  • Weilun Chao

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Center for X-Ray Optics, Lawrence Berkeley Laboratory)

  • Erik H. Anderson

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Center for X-Ray Optics, Lawrence Berkeley Laboratory)

  • Elliot R. Bernstein

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University)

  • Dean C. Crick

    (Immunology and Pathology, Colorado State University)

  • Jorge J. Rocca

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University
    Colorado State University)

  • Carmen S. Menoni

    (NSF Center for Extreme Ultraviolet Science and Technology, Colorado State University
    Colorado State University
    Colorado State University)

Abstract

Analytical probes capable of mapping molecular composition at the nanoscale are of critical importance to materials research, biology and medicine. Mass spectral imaging makes it possible to visualize the spatial organization of multiple molecular components at a sample’s surface. However, it is challenging for mass spectral imaging to map molecular composition in three dimensions (3D) with submicron resolution. Here we describe a mass spectral imaging method that exploits the high 3D localization of absorbed extreme ultraviolet laser light and its fundamentally distinct interaction with matter to determine molecular composition from a volume as small as 50 zl in a single laser shot. Molecular imaging with a lateral resolution of 75 nm and a depth resolution of 20 nm is demonstrated. These results open opportunities to visualize chemical composition and chemical changes in 3D at the nanoscale.

Suggested Citation

  • Ilya Kuznetsov & Jorge Filevich & Feng Dong & Mark Woolston & Weilun Chao & Erik H. Anderson & Elliot R. Bernstein & Dean C. Crick & Jorge J. Rocca & Carmen S. Menoni, 2015. "Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry," Nature Communications, Nature, vol. 6(1), pages 1-6, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7944
    DOI: 10.1038/ncomms7944
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