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A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Author

Listed:
  • Jianning Lu

    (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University)

  • Ceng Luo

    (Institute of Neuroscience, Fourth Military Medical University)

  • Kiran Kumar Bali

    (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University)

  • Rou-Gang Xie

    (Institute of Neuroscience, Fourth Military Medical University)

  • Richard E. Mains

    (University of Connecticut Health Center)

  • Betty A. Eipper

    (University of Connecticut Health Center
    University of Connecticut Health Center)

  • Rohini Kuner

    (Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University)

Abstract

Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.

Suggested Citation

  • Jianning Lu & Ceng Luo & Kiran Kumar Bali & Rou-Gang Xie & Richard E. Mains & Betty A. Eipper & Rohini Kuner, 2015. "A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7820
    DOI: 10.1038/ncomms7820
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