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Regulation of systemic energy homeostasis by serotonin in adipose tissues

Author

Listed:
  • Chang-Myung Oh

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

  • Jun Namkung

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
    Yonsei University Wonju College of Medicine)

  • Younghoon Go

    (Kyungpook National University Hospital, Kyungpook National University School of Medicine)

  • Ko Eun Shong

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

  • Kyuho Kim

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

  • Hyeongseok Kim

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

  • Bo-Yoon Park

    (Kyungpook National University Hospital, Kyungpook National University School of Medicine
    BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Kyungpook National University School of Medicine)

  • Ho Won Lee

    (Kyungpook National University Hospital, Kyungpook National University School of Medicine)

  • Yong Hyun Jeon

    (Kyungpook National University Hospital, Kyungpook National University School of Medicine
    Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Kyungpook National University School of Medicine)

  • Junghan Song

    (Seoul National University Bundang Hospital, Seoul National University College of Medicine)

  • Minho Shong

    (Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine)

  • Vijay K. Yadav

    (Wellcome Trust Sanger Institute)

  • Gerard Karsenty

    (Columbia University Medical Center)

  • Shingo Kajimura

    (Diabetes Center, University of California San Francisco)

  • In-Kyu Lee

    (Kyungpook National University Hospital, Kyungpook National University School of Medicine
    BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Kyungpook National University School of Medicine)

  • Sangkyu Park

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology
    College of Medicine, Catholic Kwandong University)

  • Hail Kim

    (BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

Abstract

Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.

Suggested Citation

  • Chang-Myung Oh & Jun Namkung & Younghoon Go & Ko Eun Shong & Kyuho Kim & Hyeongseok Kim & Bo-Yoon Park & Ho Won Lee & Yong Hyun Jeon & Junghan Song & Minho Shong & Vijay K. Yadav & Gerard Karsenty & S, 2015. "Regulation of systemic energy homeostasis by serotonin in adipose tissues," Nature Communications, Nature, vol. 6(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7794
    DOI: 10.1038/ncomms7794
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    Cited by:

    1. Haushabhau S. Pagire & Suvarna H. Pagire & Byung-kwan Jeong & Won-Il Choi & Chang Joo Oh & Chae Won Lim & Minhee Kim & Jihyeon Yoon & Seong Soon Kim & Myung Ae Bae & Jae-Han Jeon & Sungmin Song & Hee , 2024. "Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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