IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms7793.html
   My bibliography  Save this article

Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Author

Listed:
  • Xianbo Zuo

    (No. 1 Hospital, Anhui Medical University
    Huashan Hospital, Fudan University
    No.2 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University)

  • Liangdan Sun

    (No. 1 Hospital, Anhui Medical University
    Huashan Hospital, Fudan University
    No.2 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University)

  • Xianyong Yin

    (No. 1 Hospital, Anhui Medical University
    Huashan Hospital, Fudan University
    No.2 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University)

  • Jinping Gao

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Yujun Sheng

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Jinhua Xu

    (Huashan Hospital, Fudan University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University)

  • Jianzhong Zhang

    (Peking University People’s Hospital)

  • Chundi He

    (No.1 Hospital of China Medical University)

  • Ying Qiu

    (Jining No. 1 People’s Hospital)

  • Guangdong Wen

    (Peking University People’s Hospital)

  • Hongqing Tian

    (Shandong Provincial Institute of Dermatology and Venereology)

  • Xiaodong Zheng

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Shengxiu Liu

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Wenjun Wang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Weiran Li

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Yuyan Cheng

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Longdan Liu

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Yan Chang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Zaixing Wang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Zenggang Li

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Longnian Li

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Jianping Wu

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Ling Fang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Changbing Shen

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Fusheng Zhou

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Bo Liang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Gang Chen

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Hui Li

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Yong Cui

    (Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education
    Key Lab of Gene Resources Utilization for Severe Inherited Disorders)

  • Aie Xu

    (The Third People's Hospital of Hangzhou)

  • Xueqin Yang

    (General Hospital of PLA Air Force)

  • Fei Hao

    (Southwest Hospital, Third Military Medical University)

  • Limin Xu

    (Tianjin Changzheng Hospital)

  • Xing Fan

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Yuzhen Li

    (Second Affiliated Hospital of Harbin Medical University)

  • Rina Wu

    (The Affiliated Hospital of Inner Mongolia Medical College)

  • Xiuli Wang

    (Shanghai Skin Diseases and STD Hospital)

  • Xiaoming Liu

    (The First Affiliated Hospital of Dalian Medical University)

  • Min Zheng

    (The Second Affiliated Hospital, Zhejiang University School of Medicine)

  • Shunpeng Song

    (Dalian Dermatosis Hosptial)

  • Bihua Ji

    (Yijishan Hospital of Wannan Medical College)

  • Hong Fang

    (The First Affiliated Hospital of Zhejiang University School of Medicine)

  • Jianbin Yu

    (The First Affiliated Hospital of Zhengzhou University)

  • Yongxin Sun

    (Anshan Tanggangzi hosptial)

  • Yan Hui

    (First Affiliated Hospital of Xinjiang Medical University)

  • Furen Zhang

    (Shandong Provincial Institute of Dermatology and Venereology)

  • Rongya Yang

    (General Hospital of Beijing Military Command)

  • Sen Yang

    (No. 1 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University
    State Key Lab Incubation of Dermatology, Ministry of Science and Technology
    Key Lab of Dermatology, Ministry of Education)

  • Xuejun Zhang

    (No. 1 Hospital, Anhui Medical University
    Huashan Hospital, Fudan University
    No.2 Hospital, Anhui Medical University
    Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University)

Abstract

Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P

Suggested Citation

  • Xianbo Zuo & Liangdan Sun & Xianyong Yin & Jinping Gao & Yujun Sheng & Jinhua Xu & Jianzhong Zhang & Chundi He & Ying Qiu & Guangdong Wen & Hongqing Tian & Xiaodong Zheng & Shengxiu Liu & Wenjun Wang , 2015. "Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7793
    DOI: 10.1038/ncomms7793
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms7793
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms7793?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7793. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.