Author
Listed:
- Susan Cheng
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Brigham and Women’s Hospital, Harvard Medical School)
- Martin G. Larson
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Boston University)
- Elizabeth L. McCabe
(Boston University School of Public Health)
- Joanne M. Murabito
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Boston University School of Medicine)
- Eugene P. Rhee
(Massachusetts General Hospital, Harvard Medical School)
- Jennifer E. Ho
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Massachusetts General Hospital, Harvard Medical School
Boston University School of Medicine)
- Paul F. Jacques
(Tufts University)
- Anahita Ghorbani
(Massachusetts General Hospital, Harvard Medical School)
- Martin Magnusson
(Lund University)
- Amanda L. Souza
(Broad Institute of MIT and Harvard)
- Amy A. Deik
(Broad Institute of MIT and Harvard)
- Kerry A. Pierce
(Broad Institute of MIT and Harvard)
- Kevin Bullock
(Broad Institute of MIT and Harvard)
- Christopher J. O’Donnell
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Massachusetts General Hospital, Harvard Medical School
National Heart)
- Olle Melander
(Lund University)
- Clary B. Clish
(Broad Institute of MIT and Harvard)
- Ramachandran S. Vasan
(Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine
Boston University School of Medicine
Boston University School of Medicine)
- Robert E. Gerszten
(Massachusetts General Hospital, Harvard Medical School
Broad Institute of MIT and Harvard
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School)
- Thomas J. Wang
(Vanderbilt University)
Abstract
Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Higher concentrations of isocitrate, but not taurocholate, are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways related to human longevity are linked to the risk of common causes of death.
Suggested Citation
Susan Cheng & Martin G. Larson & Elizabeth L. McCabe & Joanne M. Murabito & Eugene P. Rhee & Jennifer E. Ho & Paul F. Jacques & Anahita Ghorbani & Martin Magnusson & Amanda L. Souza & Amy A. Deik & Ke, 2015.
"Distinct metabolomic signatures are associated with longevity in humans,"
Nature Communications, Nature, vol. 6(1), pages 1-10, November.
Handle:
RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7791
DOI: 10.1038/ncomms7791
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Citations
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Cited by:
- Fenglei Wang & Anne-Julie Tessier & Liming Liang & Clemens Wittenbecher & Danielle E. Haslam & Gonzalo Fernández-Duval & A. Heather Eliassen & Kathryn M. Rexrode & Deirdre K. Tobias & Jun Li & Oana Ze, 2023.
"Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals,"
Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Aarthi Ravikrishnan & Indrik Wijaya & Eileen Png & Kern Rei Chng & Eliza Xin Pei Ho & Amanda Hui Qi Ng & Ahmad Nazri Mohamed Naim & Jean-Sebastien Gounot & Shou Ping Guan & Jasinda Lee Hanqing & Lihua, 2024.
"Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
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