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Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

Author

Listed:
  • Jongshin Kim

    (Graduate School of Medical Science and Engineering, KAIST)

  • Haiin Jo

    (Graduate School of Medical Science and Engineering, KAIST)

  • Hyowon Hong

    (Graduate School of Medical Science and Engineering, KAIST)

  • Min Hwan Kim

    (Graduate School of Medical Science and Engineering, KAIST)

  • Jin Man Kim

    (Graduate School of Medical Science and Engineering, KAIST)

  • June-Koo Lee

    (Graduate School of Medical Science and Engineering, KAIST)

  • Won Do Heo

    (KAIST
    Center for Cognition and Sociality, Institute for Basic Science (IBS))

  • Joon Kim

    (Graduate School of Medical Science and Engineering, KAIST)

Abstract

Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis.

Suggested Citation

  • Jongshin Kim & Haiin Jo & Hyowon Hong & Min Hwan Kim & Jin Man Kim & June-Koo Lee & Won Do Heo & Joon Kim, 2015. "Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7781
    DOI: 10.1038/ncomms7781
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    Cited by:

    1. Shalmali Shukla & Ronny Haenold & Pavel Urbánek & Lucien Frappart & Shamci Monajembashi & Paulius Grigaravicius & Sigrun Nagel & Woo Kee Min & Alicia Tapias & Olivier Kassel & Heike Heuer & Zhao-Qi Wa, 2021. "TRIP6 functions in brain ciliogenesis," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Muqing Cao & Xiaoxiao Zou & Chaoyi Li & Zaisheng Lin & Ni Wang & Zhongju Zou & Youqiong Ye & Joachim Seemann & Beth Levine & Zaiming Tang & Qing Zhong, 2023. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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